Correlation of ultrasound parameter imaging with microcirculatory patterns in uveal melanomas

Ronald H Silverman; Robert Folberg; H.Culver Boldt; Harriet O Lloyd; Mark J Rondeau; Mary G Mehaffey; Frederic L Lizzi; D.Jackson Coleman

doi:10.1016/S0301-5629(97)00037-9

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Correlation of ultrasound parameter imaging with microcirculatory patterns in uveal melanomas

Journal article

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Correlation of ultrasound parameter imaging with microcirculatory patterns in uveal melanomas

Ronald H Silverman, Robert Folberg, H.Culver Boldt, Harriet O Lloyd, Mark J Rondeau, Mary G Mehaffey, Frederic L Lizzi and D.Jackson Coleman

Ultrasound in medicine & biology, Vol.23(4), pp.573-581

01/1997

DOI: 10.1016/S0301-5629(97)00037-9

PMID: 9232766

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Abstract

Previous studies demonstrated a correlation between acoustic backscatter parameters and survival in ocular melanoma. The histologic presence of microvascular networks in ocular melanoma is also associated with death from metastases. This study tests the hypothesis that melanomas grouped on the basis of these microvascular patterns are separable by ultrasound spectrum analysis. We scanned 40 melanomas using a 10-MHz ultrasound unit equipped for digitization of radio frequency data. After enucleation, tumors were sectioned in planes corresponding to the ultrasonographic examination and stained to demonstrate microcirculation. Acoustic spectral parameters were compared between 14 melanomas with a nevuslike microcirculation and 26 with foci of high-risk microvascular structures. Smaller scatterer size, lower acoustic concentration and greater spatial variability were found to correlate with high-risk microvascular patterns and areas of cystic degeneration. We suggest that nonvascular extracellular matrix components associated with microvessels may be responsible for the correlation of acoustic parameters with microvascular pattern and distribution.

Details

Title: Subtitle: Correlation of ultrasound parameter imaging with microcirculatory patterns in uveal melanomas
Creators: Ronald H Silverman
Robert Folberg
H.Culver Boldt
Harriet O Lloyd
Mark J Rondeau
Mary G Mehaffey
Frederic L Lizzi
D.Jackson Coleman
Resource Type: Journal article
Publication Details: Ultrasound in medicine & biology, Vol.23(4), pp.573-581
DOI: 10.1016/S0301-5629(97)00037-9
PMID: 9232766
NLM abbreviation: Ultrasound Med Biol
ISSN: 0301-5629
eISSN: 1879-291X
Language: English
Date published: 01/1997
Academic Unit: Ophthalmology and Visual Sciences
Record Identifier: 9984083256702771

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