Correlations of Medial Joint Space Width on Fixed-Flexed Standing Computed Tomography and Radiographs With Cartilage and Meniscal Morphology on Magnetic Resonance Imaging

N A Segal; E Frick; J Duryea; F Roemer; A Guermazi; M C Nevitt; J C Torner; D T Felson; D D Anderson

doi:10.1002/acr.22888

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Correlations of Medial Joint Space Width on Fixed-Flexed Standing Computed Tomography and Radiographs With Cartilage and Meniscal Morphology on Magnetic Resonance Imaging

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Correlations of Medial Joint Space Width on Fixed-Flexed Standing Computed Tomography and Radiographs With Cartilage and Meniscal Morphology on Magnetic Resonance Imaging

N A Segal, E Frick, J Duryea, F Roemer, A Guermazi, M C Nevitt, J C Torner, D T Felson and D D Anderson

Arthritis care & research (2010), Vol.68(10), pp.1410-1416

10/2016

DOI: 10.1002/acr.22888

PMCID: PMC5027176

PMID: 26991547

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Abstract

To assess whether medial tibiofemoral joint space width (JSW) on 3-dimensional (3-D) standing computed tomography (SCT) correlates more closely with magnetic resonance imaging cartilage morphology (CM) and meniscal scores than does radiographic 2-D JSW. Participants in the Multicenter Osteoarthritis Study, who had standing fixed-flexion posteroanterior knee radiographs, were recruited. Medial tibiofemoral 3-D JSW on SCT and 2-D JSW on fixed-flexion radiographs were compared with medial tibiofemoral cartilage and meniscal morphology using the Whole-Organ Magnetic Resonance Imaging Score (WORMS). Associations between the area of the articular surface with 3-D JSW <2.5 mm on SCT, radiographic minimal 2-D JSW, and the WORMS-CM and meniscal scores were assessed using Spearman's rho. For the 19 participants included (33 knees), mean ± SD age was 66.9 ± 5.4 years, body mass index was 29.5 ± 4.4 kg/m(2) , 42.1% of participants were female, and the Kellgren/Lawrence grades were 0 (21.2%), 1 (36.4%), 2 (18.2%), and 3 (24.2%). The articular surface area with 3-D JSW <2.5 mm on SCT correlated with WORMS-CM scores for the central medial tibia (rs = 0.84, P < 0.001), central medial femur (rs = 0.60, P < 0.007), and posterior medial meniscal tear (rs = 0.39, P < 0.026), as did other cut points for 3-D JSW. Correlations with radiographic minimal 2-D JSW were -0.66, -0.52, and -0.40, respectively, differing from SCT only for tibial cartilage (P = 0.001). Greater surface area with a low JSW, measured by SCT, correlates more strongly with the severity of tibial cartilage lesions, while correlating with medial femoral cartilage and meniscal damage to a similar extent as radiographic minimal JSW. SCT may enable valid stratification of participants in clinical trials, through quickly and inexpensively characterizing osteoarthritis features.

Cartilage, Articular - diagnostic imaging

Humans

Middle Aged

Knee Joint - diagnostic imaging

Tibia - diagnostic imaging

Male

Tomography, X-Ray Computed

Femur - diagnostic imaging

Osteoarthritis, Knee - diagnostic imaging

Posture

Radiography

Cartilage, Articular - pathology

Magnetic Resonance Imaging

Knee Joint - pathology

Menisci, Tibial - pathology

Osteoarthritis, Knee - pathology

Female

Aged

Menisci, Tibial - diagnostic imaging

Details

Title: Subtitle: Correlations of Medial Joint Space Width on Fixed-Flexed Standing Computed Tomography and Radiographs With Cartilage and Meniscal Morphology on Magnetic Resonance Imaging
Creators: N A Segal - University of Kansas, Kansas City, and University of Iowa, Iowa City. segal-research@kumc.edu
E Frick - University of Iowa, Iowa City
J Duryea - Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts
F Roemer - Boston University, Boston, Massachusetts
A Guermazi - Boston University, Boston, Massachusetts
M C Nevitt - University of California, San Francisco
J C Torner - University of Iowa, Iowa City
D T Felson - Boston University, Boston, Massachusetts
D D Anderson - University of Iowa, Iowa City
Resource Type: Journal article
Publication Details: Arthritis care & research (2010), Vol.68(10), pp.1410-1416
DOI: 10.1002/acr.22888
PMID: 26991547
PMCID: PMC5027176
NLM abbreviation: Arthritis Care Res (Hoboken)
ISSN: 2151-464X
eISSN: 2151-4658
Publisher: United States
Grant note: U01 AG018947 / NIA NIH HHS U01 AG018832 / NIA NIH HHS P50 AR055533 / NIAMS NIH HHS U01 AG019069 / NIA NIH HHS U01 AG018820 / NIA NIH HHS
Language: English
Date published: 10/2016
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Iowa Technology Institute; Epidemiology; Orthopedics and Rehabilitation; Surgery; Industrial and Systems Engineering; Injury Prevention Research Center; Neurosurgery
Record Identifier: 9983995130302771

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