Journal article
Correspondence between the alcohol-P3 event-related potential and alcohol reward phenotypes among young adults
Alcohol, clinical & experimental research, Vol.48(7), pp.1302-1312
07/2024
DOI: 10.1111/acer.15377
PMCID: PMC12848482
PMID: 38831377
Abstract
BACKGROUND Behavioral economic theory suggests that the value of alcohol depends upon elements of the choice context, such that increasing constraints on alternatives (e.g., price) or increasing the benefits of alcohol (e.g., social context) may result in greater likelihood of heavy drinking. The P3 event-related potential elicited by alcohol-related cues, a proposed marker of incentive salience, may be an electrophysiological parallel for behavioral economic alcohol demand. However, these indices have not been connected in prior research, and studies typically do not disaggregate social influences in the context of alcohol cue reactivity. METHOD The current study recruited heavy drinking young adults (N = 81) who completed measures of alcohol use and alcohol demand, in addition to a 2 (social/nonsocial) × 2 (alcohol/nonalcohol) visual oddball task to elicit the P3. RESULTS In multilevel models controlling for demographic characteristics, P3 reactivity was greater to alcohol (p < 0.001) and social (p < 0.001) cues than to nonalcohol and nonsocial cues, but without a significant interaction. Higher alcohol consumption (p = 0.02) and lower elasticity of demand (p = 0.01) were associated with greater P3 response to alcohol than nonalcohol cues .CONCLUSIONS The results highlight a brain-behavior connection that may be an important marker for alcohol reward across units of analysis and may be sensitive to changes in the economic choice contexts that influence the likelihood of alcohol use.
Details
- Title: Subtitle
- Correspondence between the alcohol-P3 event-related potential and alcohol reward phenotypes among young adults
- Creators
- Samuel F AcuffRoberto U CofresíAustin VarnerAshley A DennhardtJeffrey J SableBruce D BartholowJames MacKillopJames G Murphy
- Resource Type
- Journal article
- Publication Details
- Alcohol, clinical & experimental research, Vol.48(7), pp.1302-1312
- DOI
- 10.1111/acer.15377
- PMID
- 38831377
- PMCID
- PMC12848482
- eISSN
- 2993-7175
- Language
- English
- Electronic publication date
- 06/03/2024
- Date published
- 07/2024
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984634258402771
Metrics
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