Journal article
Cortical Control of Affective Networks
The Journal of neuroscience, Vol.33(3), pp.1116-1129
01/16/2013
DOI: 10.1523/JNEUROSCI.0092-12.2013
PMCID: PMC3711588
PMID: 23325249
Abstract
Transcranial magnetic stimulation and deep brain stimulation have emerged as therapeutic modalities for treatment refractory depression; however, little remains known regarding the circuitry that mediates the therapeutic effect of these approaches. Here we show that direct optogenetic stimulation of prefrontal cortex (PFC) descending projection neurons in mice engineered to express Chr2 in layer V pyramidal neurons (Thy1–Chr2 mice) models an antidepressant-like effect in mice subjected to a forced-swim test. Furthermore, we show that this PFC stimulation induces a long-lasting suppression of anxiety-like behavior (but not conditioned social avoidance) in socially stressed Thy1–Chr2 mice: an effect that is observed >10 d after the last stimulation. Finally, we use optogenetic stimulation and multicircuit recording techniques concurrently in Thy1–Chr2 mice to demonstrate that activation of cortical projection neurons entrains neural oscillatory activity and drives synchrony across limbic brain areas that regulate affect. Importantly, these neural oscillatory changes directly correlate with the temporally precise activation and suppression of limbic unit activity. Together, our findings show that the direct activation of cortical projection systems is sufficient to modulate activity across networks underlying affective regulation. They also suggest that optogenetic stimulation of cortical projection systems may serve as a viable therapeutic strategy for treating affective disorders.
Details
- Title: Subtitle
- Cortical Control of Affective Networks
- Creators
- Sunil Kumar - Department of Psychiatry and Behavioral SciencesRainbo Hultman - Psychology and Neuroscience, Duke University, Durham, North Carolina 27708, andSherilynn J Black - Department of Psychiatry and Behavioral SciencesSteven T Szabo - Department of Psychiatry and Behavioral SciencesKristine D DeMaio - Psychology and Neuroscience, Duke University, Durham, North Carolina 27708, andJeanette Du - Psychology and Neuroscience, Duke University, Durham, North Carolina 27708, andBrittany M Katz - Department of Psychiatry and Behavioral SciencesGuoping Feng - Department of Brain and Cognitive Sciences, McGovern Institute for Brain Research at Massachusetts Institute of Technology, Cambridge, Massachusetts 02139Herbert E Covington - Duke Institute for Brain Sciences, Duke University Medical Center, Durham, North Carolina 27710Kafui Dzirasa - Department of Psychiatry and Behavioral Sciences
- Resource Type
- Journal article
- Publication Details
- The Journal of neuroscience, Vol.33(3), pp.1116-1129
- Publisher
- Society for Neuroscience
- DOI
- 10.1523/JNEUROSCI.0092-12.2013
- PMID
- 23325249
- PMCID
- PMC3711588
- ISSN
- 0270-6474
- eISSN
- 1529-2401
- Language
- English
- Date published
- 01/16/2013
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984065750002771
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