Cortical Features in Child and Adolescent Carriers of Mutant Huntingtin (mHTT)

Erin E Reasoner; Ellen van der Plas; Douglas R Langbehn; Amy L Conrad; Timothy R Koscik; Eric A Epping; Vincent A Magnotta; Peggy C Nopoulos

doi:10.3233/JHD-210512

Back

Cortical Features in Child and Adolescent Carriers of Mutant Huntingtin (mHTT)

Journal article

Peer reviewed

Cortical Features in Child and Adolescent Carriers of Mutant Huntingtin (mHTT)

Erin E Reasoner, Ellen van der Plas, Douglas R Langbehn, Amy L Conrad, Timothy R Koscik, Eric A Epping, Vincent A Magnotta and Peggy C Nopoulos

Journal of Huntington's disease, Vol.11(2), pp.173-178

06/03/2022

DOI: 10.3233/JHD-210512

PMCID: PMC9177765

PMID: 35275555

Files and links (1)

url

https://www.ncbi.nlm.nih.gov/pmc/articles/9177765View

Open Access

Abstract

Molecular studies provide evidence that mutant huntingtin (mHTT) affects early cortical development; however, cortical development has not been evaluated in child and adolescent carriers of mHTT. To evaluate the impact of mHTT on the developmental trajectories of cortical thickness and surface area. Children and adolescents (6-18 years) participated in the KidsHD study. mHTT carrier status was determined for research purposes only to classify participants as gene expanded (GE) and gene non-expanded (GNE). Cortical features were extracted from 3T neuroimaging using FreeSurfer. Nonlinear mixed effects models were conducted to determine if age, group, and CAG repeat were associated with cortical morphometry. Age-related changes in cortical morphometry were similar across groups. Expanded CAG repeat was not significantly associated with cortical features. While striatal development is markedly different in GE and GNE, developmental change of the cortex appears grossly normal among child and adolescent carrier of mHTT.

Magnetic Resonance Imaging

children at risk for HD

Huntington’s disease

trinucleotide repeat disorder

cortical development

Details

Title: Subtitle: Cortical Features in Child and Adolescent Carriers of Mutant Huntingtin (mHTT)
Creators: Erin E Reasoner - University of Iowa
Ellen van der Plas - University of Iowa
Douglas R Langbehn - University of Iowa
Amy L Conrad - University of Iowa
Timothy R Koscik - University of Iowa
Eric A Epping - University of Iowa
Vincent A Magnotta - University of Iowa
Peggy C Nopoulos - University of Iowa
Resource Type: Journal article
Publication Details: Journal of Huntington's disease, Vol.11(2), pp.173-178
DOI: 10.3233/JHD-210512
PMID: 35275555
PMCID: PMC9177765
NLM abbreviation: J Huntingtons Dis
ISSN: 1879-6397
eISSN: 1879-6400
Language: English
Electronic publication date: 03/07/2022
Date published: 06/03/2022
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Neurology; Radiology; Psychiatry; Pediatric Psychology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Craniofacial Anomalies Research Center
Record Identifier: 9984227002602771

Metrics

20 Record Views

4 Times Cited - Web of Science