Cortical Responses to Vowel Sequences in Awake and Anesthetized States: A Human Intracranial Electrophysiology Study

Kirill V Nourski; Mitchell Steinschneider; Ariane E Rhone; Bryan M Krause; Rashmi N Mueller; Hiroto Kawasaki; Matthew I Banks

doi:10.1093/cercor/bhab168

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Cortical Responses to Vowel Sequences in Awake and Anesthetized States: A Human Intracranial Electrophysiology Study

Journal article

Open access

Peer reviewed

Cortical Responses to Vowel Sequences in Awake and Anesthetized States: A Human Intracranial Electrophysiology Study

Kirill V Nourski, Mitchell Steinschneider, Ariane E Rhone, Bryan M Krause, Rashmi N Mueller, Hiroto Kawasaki and Matthew I Banks

Cerebral cortex (New York, N.Y. 1991), Vol.31(12), pp.5435-5448

10/22/2021

DOI: 10.1093/cercor/bhab168

PMCID: PMC8568007

PMID: 34117741

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568007View

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Abstract

Elucidating neural signatures of sensory processing across consciousness states is a major focus in neuroscience. Noninvasive human studies using the general anesthetic propofol reveal differential effects on auditory cortical activity, with a greater impact on nonprimary and auditory-related areas than primary auditory cortex. This study used intracranial electroencephalography to examine cortical responses to vowel sequences during induction of general anesthesia with propofol. Subjects were adult neurosurgical patients with intracranial electrodes placed to identify epileptic foci. Data were collected before electrode removal surgery. Stimuli were vowel sequences presented in a target detection task during awake, sedated, and unresponsive states. Averaged evoked potentials (AEPs) and high gamma (70-150 Hz) power were measured in auditory, auditory-related, and prefrontal cortex. In the awake state, AEPs were found throughout studied brain areas; high gamma activity was limited to canonical auditory cortex. Sedation led to a decrease in AEP magnitude. Upon LOC, there was a decrease in the superior temporal gyrus and adjacent auditory-related cortex and a further decrease in AEP magnitude in core auditory cortex, changes in the temporal structure and increased trial-to-trial variability of responses. The findings identify putative biomarkers of LOC and serve as a foundation for future investigations of altered sensory processing.

Acoustic Stimulation

Adult

Auditory Cortex - physiology

Electroencephalography

Electrophysiology

Evoked Potentials, Auditory - physiology

Humans

Wakefulness

Details

Title: Subtitle: Cortical Responses to Vowel Sequences in Awake and Anesthetized States: A Human Intracranial Electrophysiology Study
Creators: Kirill V Nourski - University of Iowa
Mitchell Steinschneider - Albert Einstein College of Medicine
Ariane E Rhone - University of Iowa
Bryan M Krause - University of Wisconsin–Madison
Rashmi N Mueller - University of Iowa
Hiroto Kawasaki - University of Iowa
Matthew I Banks - University of Wisconsin–Madison
Resource Type: Journal article
Publication Details: Cerebral cortex (New York, N.Y. 1991), Vol.31(12), pp.5435-5448
DOI: 10.1093/cercor/bhab168
PMID: 34117741
PMCID: PMC8568007
NLM abbreviation: Cereb Cortex
ISSN: 1047-3211
eISSN: 1460-2199
Grant note: UL1 RR024979 / NCRR NIH HHS R01 DC004290 / NIDCD NIH HHS R01 GM109086 / NIGMS NIH HHS P50 HD105352 / NICHD NIH HHS
Language: English
Date published: 10/22/2021
Academic Unit: Iowa Neuroscience Institute; Anesthesia; Neurosurgery
Record Identifier: 9984256841102771

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