Cortical and Cerebellar Oscillatory Responses to Postural Instability in Parkinson's Disease

Taylor J. Bosch; Stefan Kammermeier; Christopher Groth; Matt Leedom; Elizabeth K. Hanson; Patti Berg-Poppe; Arun Singh

doi:10.3389/fneur.2021.752271

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Cortical and Cerebellar Oscillatory Responses to Postural Instability in Parkinson's Disease

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Cortical and Cerebellar Oscillatory Responses to Postural Instability in Parkinson's Disease

Taylor J. Bosch, Stefan Kammermeier, Christopher Groth, Matt Leedom, Elizabeth K. Hanson, Patti Berg-Poppe and Arun Singh

Frontiers in neurology, Vol.12, pp.752271-752271

11/04/2021

DOI: 10.3389/fneur.2021.752271

PMCID: PMC8599431

PMID: 34803888

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Abstract

Introduction: Posture and balance dysfunctions critically impair activities of daily living of patients with progressing Parkinson's disease (PD). However, the neural mechanisms underlying postural instability in PD are poorly understood, and specific therapies are lacking. Previous electrophysiological studies have shown distinct cortical oscillations with a significant contribution of the cerebellum during postural control tasks in healthy individuals.Methods: We investigated cortical and mid-cerebellar oscillatory activity via electroencephalography (EEG) during a postural control task in 10 PD patients with postural instability (PDPI+), 11 PD patients without postural instability (PDPI-), and 15 age-matched healthy control participants. Relative spectral power was analyzed in the theta (4-7 Hz) and beta (13-30 Hz) frequency bands.Results: Time-dependent postural measurements computed by accelerometer signals showed poor performance in PDPI+ participants. EEG results revealed that theta power was profoundly lower in mid-frontal and mid-cerebellar regions during the postural control task in PDPI+, compared to PDPI- and control participants. In addition, theta power was correlated with postural control performance in PD subjects. No significant changes in beta power were observed. Additionally, oscillatory changes during the postural control task differed from the resting state.Conclusion: This study underlines the involvement of mid-frontal and mid-cerebellar regions in postural stability during a balance task and emphasizes the important role of theta oscillations therein for postural control in PD.

Clinical Neurology

Life Sciences & Biomedicine

Neurosciences

Neurosciences & Neurology

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Details

Title: Subtitle: Cortical and Cerebellar Oscillatory Responses to Postural Instability in Parkinson's Disease
Creators: Taylor J. Bosch - University of South Dakota
Stefan Kammermeier - Ludwig-Maximilians-Universität München
Christopher Groth - University of Iowa
Matt Leedom - Avera Health
Elizabeth K. Hanson - University of South Dakota
Patti Berg-Poppe - University of South Dakota
Arun Singh - University of South Dakota
Resource Type: Journal article
Publication Details: Frontiers in neurology, Vol.12, pp.752271-752271
DOI: 10.3389/fneur.2021.752271
PMID: 34803888
PMCID: PMC8599431
NLM abbreviation: Front Neurol
ISSN: 1664-2295
eISSN: 1664-2295
Publisher: Frontiers Media Sa
Number of pages: 11
Grant note: Division of Basic Biomedical Sciences at the University of South Dakota, Vermillion, SD, USA Center for Brain and Behavior Research (CBBRe) at the University of South Dakota, Vermillion, SD, USA
Language: English
Date published: 11/04/2021
Academic Unit: Neurology
Record Identifier: 9984303019602771

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