Journal article
Cortical and subcortical functional connectivity and cognitive impairment in Parkinson’s disease
NeuroImage clinical, Vol.42, 103610
04/25/2024
DOI: 10.1016/j.nicl.2024.103610
PMCID: PMC11066685
PMID: 38677099
Abstract
•Cognitive dysfunction is a prominent clinical symptom in Parkinson’s disease.•We found that cognitive dysfunction in PD was linked with decreased intra-network frontoparietal connectivity.•We also found that cognitive dysfunction in PD was linked with decreased inter-network connectivity of the salience network, default mode network, and basal ganglia network.
Parkinson’s disease (PD) is a neurodegenerative disease with cognitive as well as motor impairments. While much is known about the brain networks leading to motor impairments in PD, less is known about the brain networks contributing to cognitive impairments. Here, we leveraged resting-state functional magnetic resonance imaging (rs-fMRI) data from the Parkinson’s Progression Marker Initiative (PPMI) to examine network dysfunction in PD patients with cognitive impairment. We focus on canonical cortical networks linked to cognition, including the salience network (SAL), frontoparietal network (FPN), and default mode network (DMN), as well as a subcortical basal ganglia network (BGN). We used the Montreal Cognitive Assessment (MoCA) as a continuous index of coarse cognitive function in PD. In 82 PD patients, we found that lower MOCA scores were linked with lower intra-network connectivity of the FPN. Second, we found that lower MOCA scores were linked with lower inter-network connectivity between the SAL and the BGN, the SAL and the DMN, as well as the FPN and the DMN. These data elucidate the relationship of cortical and subcortical functional connectivity with cognitive impairments in PD.
Details
- Title: Subtitle
- Cortical and subcortical functional connectivity and cognitive impairment in Parkinson’s disease
- Creators
- Brooke E. Yeager - University of IowaHunter P. Twedt - University of IowaJoel Bruss - University of IowaJordan Schultz - University of IowaNandakumar S. Narayanan - University of Iowa
- Resource Type
- Journal article
- Publication Details
- NeuroImage clinical, Vol.42, 103610
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.nicl.2024.103610
- PMID
- 38677099
- PMCID
- PMC11066685
- ISSN
- 2213-1582
- eISSN
- 2213-1582
- Language
- English
- Date published
- 04/25/2024
- Academic Unit
- Neurology; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Pharmacy Practice and Science
- Record Identifier
- 9984619459902771
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