Journal article
Cortical inhibition in motor and non-motor regions: a combined TMS-EEG study
Clinical EEG and neuroscience, Vol.39(3), pp.112-117
07/01/2008
DOI: 10.1177/155005940803900304
PMID: 18751559
Abstract
A number of studies using paired pulse transcranial magnetic stimulation (TMS) have demonstrated that cortical inhibition (CI) of the motor cortex can be recorded and also gauged through surface electromyography. However, recording CI from other brain regions that are more directly related with the pathophysiology of some neurologic and psychiatric disorders (e.g., dorsolateral prefrontal cortex (DLPFC) in schizophrenia) was previously fraught with technical difficulties. This study was therefore designed to examine, through a combination of TMS with EEG, whether Cl could be measured directly from the motor cortex, DLPFC and another non-motor region.
To index CI, long interval cortical inhibition (LICI; a TMS paradigm) was used in the motor cortex and DLPFC in 14 healthy subjects, and in the parietal lobe in 5 of those subjects. In the motor cortex, LICI resulted in a significant suppression in mean cortical evoked activity on EEG (37.31 +/- 47.51 %). In the DLPFC, LICI resulted in a significant suppression (32.45 +/- 47.86 %) in mean cortical evoked activity and did not correlate with LICI in the motor cortex although they did not significantly differ. In the parietal lobe, LICI resulted in significant suppression (47.76 +/- 44.70 %) in mean cortical evoked activity.
In conclusion, CI in the dorsolateral prefrontal cortex, motor cortex and panetal cortex were similar at 120% of motor threshold. These data suggest that CI can be recorded by combining TMS with EEG and may facilitate future research attempting to ascertain the role of CI in the pathophysiology of several neurologic and psychiatric disorders.
Details
- Title: Subtitle
- Cortical inhibition in motor and non-motor regions: a combined TMS-EEG study
- Creators
- Paul B. Fitzgerald - Monash UniversityZafiris J. Daskalakis - Centre for Addiction and Mental HealthKate Hoy - Monash UniversityFaranak Farzan - Centre for Addiction and Mental HealthDaniel J. Upton - Monash UniversityNicholas R. Cooper - University of EssexJerome J. Maller - Monash University
- Resource Type
- Journal article
- Publication Details
- Clinical EEG and neuroscience, Vol.39(3), pp.112-117
- DOI
- 10.1177/155005940803900304
- PMID
- 18751559
- NLM abbreviation
- Clin EEG Neurosci
- ISSN
- 1550-0594
- eISSN
- 2169-5202
- Publisher
- Sage
- Number of pages
- 6
- Grant note
- Constance and Stephen Lieber National Health and Medical Research Council (NHMRC) Practitioner Fellowship (PBF); National Health & Medical Research Council (NHMRC) of Australia
- Language
- English
- Date published
- 07/01/2008
- Academic Unit
- Radiology
- Record Identifier
- 9984848427302771
Metrics
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