Journal article
Cortical innervation of the hypoglossal nucleus in the non-human primate (Macaca mulatta)
Journal of comparative neurology (1911), Vol.522(15), pp.3456-3484
10/15/2014
DOI: 10.1002/cne.23614
PMCID: PMC4139435
PMID: 24752643
Abstract
The corticobulbar projection to the hypoglossal nucleus was studied from the frontal, parietal, cingulate, and insular cortices in the rhesus monkey by using high-resolution anterograde tracers and stereology. The hypoglossal nucleus received bilateral input from the face/head region of the primary (M1), ventrolateral pre- (LPMCv), supplementary (M2), rostral cingulate (M3), and caudal cingulate (M4) motor cortices. Additional bilateral corticohypoglossal projections were found from the dorsolateral premotor cortex (LPMCd), ventrolateral proisocortical motor area (ProM), ventrolateral primary somatosensory cortex (S1), rostral insula, and pregenual region of the anterior cingulate gyrus (areas 24/32). Dense terminal projections arose from the ventral region of M1, and moderate projections from LPMCv and rostral part of M2, with considerably fewer hypoglossal projections arising from the other cortical regions. These findings demonstrate that extensive regions of the non-human primate cerebral cortex innervate the hypoglossal nucleus. The widespread and bilateral nature of this corticobulbar connection suggests recovery of tongue movement after cortical injury that compromises a subset of these areas, may occur from spared corticohypoglossal projection areas located on the lateral, as well as medial surfaces of both hemispheres. Since functional imaging studies have shown that homologous cortical areas are activated in humans during tongue movement tasks, these corticobulbar projections may exist in the human brain.
Details
- Title: Subtitle
- Cortical innervation of the hypoglossal nucleus in the non-human primate (Macaca mulatta)
- Creators
- Robert J Morecraft - University of South DakotaKimberly S Stilwell-Morecraft - University of South DakotaKathryn M Solon-Cline - University of South DakotaJizhi Ge - University of South DakotaWarren G Darling - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of comparative neurology (1911), Vol.522(15), pp.3456-3484
- Publisher
- Blackwell Publishing Ltd
- DOI
- 10.1002/cne.23614
- PMID
- 24752643
- PMCID
- PMC4139435
- ISSN
- 0021-9967
- eISSN
- 1096-9861
- Number of pages
- 30
- Grant note
- DOI: 10.13039/100008537, name: Benign Essential Blepharospasm Research Foundation, award: 000
- Language
- English
- Date published
- 10/15/2014
- Academic Unit
- Physical Therapy and Rehabilitation Science; Health and Human Physiology
- Record Identifier
- 9984259643802771
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