Cortical neurodynamics of inhibitory control

Kai Hwang; Avniel S Ghuman; Dara S Manoach; Stephanie R Jones; Beatriz Luna

doi:10.1523/JNEUROSCI.4889-13.2014

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Cortical neurodynamics of inhibitory control

Journal article

Open access

Peer reviewed

Cortical neurodynamics of inhibitory control

Kai Hwang, Avniel S Ghuman, Dara S Manoach, Stephanie R Jones and Beatriz Luna

The Journal of neuroscience, Vol.34(29), pp.9551-9561

07/16/2014

DOI: 10.1523/JNEUROSCI.4889-13.2014

PMCID: PMC4099539

PMID: 25031398

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Abstract

The ability to inhibit prepotent responses is critical for successful goal-directed behaviors. To investigate the neural basis of inhibitory control, we conducted a magnetoencephalography study where human participants performed the antisaccade task. Results indicated that neural oscillations in the prefrontal cortex (PFC) showed significant task modulations in preparation to suppress saccades. Before successfully inhibiting a saccade, beta-band power (18-38 Hz) in the lateral PFC and alpha-band power (10-18 Hz) in the frontal eye field (FEF) increased. Trial-by-trial prestimulus FEF alpha-band power predicted successful saccadic inhibition. Further, inhibitory control enhanced cross-frequency amplitude coupling between PFC beta-band (18-38 Hz) activity and FEF alpha-band activity, and the coupling appeared to be initiated by the PFC. Our results suggest a generalized mechanism for top-down inhibitory control: prefrontal beta-band activity initiates alpha-band activity for functional inhibition of the effector and/or sensory system.

Brain Waves - physiology

Visual Fields - physiology

Magnetoencephalography

Humans

Male

Electroencephalography

Reaction Time - physiology

Young Adult

Saccades

Analysis of Variance

Brain Mapping

Adult

Female

Nonlinear Dynamics

Spectrum Analysis

Prefrontal Cortex - physiology

Inhibition (Psychology)

Details

Title: Subtitle: Cortical neurodynamics of inhibitory control
Creators: Kai Hwang - Department of Psychiatry and Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, Center for the Neural Basis of Cognition, Carnegie Mellon University and University of Pittsburgh, Pittsburgh, Pennsylvania, 15213, kah124@pitt.edu
Avniel S Ghuman - Center for the Neural Basis of Cognition, Carnegie Mellon University and University of Pittsburgh, Pittsburgh, Pennsylvania, 15213, Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213
Dara S Manoach - Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, and
Stephanie R Jones - Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, and Department of Neuroscience, Brown University, Providence, Rhode Island 02912
Beatriz Luna - Department of Psychiatry and Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, Center for the Neural Basis of Cognition, Carnegie Mellon University and University of Pittsburgh, Pittsburgh, Pennsylvania, 15213
Resource Type: Journal article
Publication Details: The Journal of neuroscience, Vol.34(29), pp.9551-9561
DOI: 10.1523/JNEUROSCI.4889-13.2014
PMID: 25031398
PMCID: PMC4099539
NLM abbreviation: J Neurosci
ISSN: 0270-6474
eISSN: 1529-2401
Publisher: United States
Grant note: R01 MH067924 / NIMH NIH HHS
Language: English
Date published: 07/16/2014
Academic Unit: Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984002340302771

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