Journal article
Cortical spreading depression as a site of origin for migraine: Role of CGRP
Cephalalgia, Vol.39(3), pp.428-434
03/2019
DOI: 10.1177/0333102418774299
PMCID: PMC7007998
PMID: 29695168
Abstract
Migraine is a complex neurologic disorder that leads to significant disability, yet remains poorly understood.
One potential triggering mechanism in migraine with aura is cortical spreading depression, which can activate the trigeminal nociceptive system both peripherally and centrally in animal models. A primary neuropeptide of the trigeminal system is calcitonin gene-related peptide, which is a potent vasodilatory peptide and is currently a major therapeutic target for migraine treatment. Despite the importance of both cortical spreading depression and calcitonin gene-related peptide in migraine, the relationship between these two players has been relatively unexplored. However, recent data suggest several potential vascular and neural connections between calcitonin gene-related peptide and cortical spreading depression.
This review will outline calcitonin gene-related peptide-cortical spreading depression connections and propose a model in which cortical spreading depression and calcitonin gene-related peptide act at the intersection of the vasculature and cortical neurons, and thus contribute to migraine pathophysiology.
Details
- Title: Subtitle
- Cortical spreading depression as a site of origin for migraine: Role of CGRP
- Creators
- Liesl N Close - 1 Department of Neurosurgery, University of Iowa, Iowa City, IA, USASajedeh Eftekhari - 2 UCLA Goldberg Migraine Program, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USAMinyan Wang - 3 Centre for Neuroscience, Department of Biological Sciences, Xi'an Jiaotong-Liverpool University (XJTLU), SIP, Suzhou, ChinaAndrew C Charles - 2 UCLA Goldberg Migraine Program, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USAAndrew F Russo - 6 Veterans Affairs Medical Center, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Cephalalgia, Vol.39(3), pp.428-434
- DOI
- 10.1177/0333102418774299
- PMID
- 29695168
- PMCID
- PMC7007998
- NLM abbreviation
- Cephalalgia
- ISSN
- 0333-1024
- eISSN
- 1468-2982
- Publisher
- England
- Grant note
- I01 RX002101 / RRD VA R01 NS075599 / NINDS NIH HHS
- Language
- English
- Date published
- 03/2019
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute; Craniofacial Anomalies Research Center
- Record Identifier
- 9984070124902771
Metrics
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