Journal article
Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3–90 years
Human brain mapping, Vol.43(1), pp.431-451
02/17/2021
DOI: 10.1002/hbm.25364
PMCID: PMC8675431
PMID: 33595143
Abstract
Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and brain morphometry require large-scale studies. In response, we used cross-sectional data from 17,075 individuals aged 3-90 years from the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to infer age-related changes in cortical thickness. We used fractional polynomial (FP) regression to quantify the association between age and cortical thickness, and we computed normalized growth centiles using the parametric Lambda, Mu, and Sigma method. Interindividual variability was estimated using meta-analysis and one-way analysis of variance. For most regions, their highest cortical thickness value was observed in childhood. Age and cortical thickness showed a negative association; the slope was steeper up to the third decade of life and more gradual thereafter; notable exceptions to this general pattern were entorhinal, temporopolar, and anterior cingulate cortices. Interindividual variability was largest in temporal and frontal regions across the lifespan. Age and its FP combinations explained up to 59% variance in cortical thickness. These results may form the basis of further investigation on normative deviation in cortical thickness and its significance for behavioral and cognitive outcomes.
Details
- Title: Subtitle
- Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3–90 years
- Creators
- Sophia FrangouAmirhossein ModabberniaSteven C. R WilliamsEfstathios PapachristouGaelle E DoucetIngrid AgartzMoji AghajaniTheophilus N AkudjeduAnton Albajes EizagirreDag AlnæsKathryn I AlpertIan B HickieYulyia YonchevaMarcus V ZanettiGeorg C ZieglerPaul M ThompsonPaola Fuentes ClaramonteTatyana P KlyushnikAurora BonvinoEco J. C GeusIan H GotlibYang WangDanai DimaKarolinska Schizophrenia ProjectDorret I BoomsmaStefan BorgwardtBeng Choon HoJosiane BourqueDaniel BrandeisAlan BreierDavid C GlahnHenry BrodatyDavid Mataix ColsAvram J HolmesLieuwe HaanRachel M BrouwerOle A AndreassenXavier CaserasFrancisco X CastellanosSimon CervenkaTiffany M Chaim AvanciniSanne KoopsChristopher R. K ChingBernard MazoyerVictoria ChubarVincent P ClarkSarah HohmannPatricia ConrodLars NybergJim LagopoulosHans Jörgen GrabeAnnette ConzelmannPerminder S SachdevGreig I ZubicarayColm McdonaldAnouk BraberErin W DickieAnnabella Di GiorgioNhat Trung DoanErlend S DørumJaap OosterlaanStefan EhrlichSusanne ErkJonna KuntsiThomas EspesethBrenna C McdonaldRaymond SalvadorNorbert HostenMartine HoogmanHelena Fatouros BergmanChristian K TamnesOliver GrimmVíctor Ortiz García FozNynke A GroenewoldDominik GrotegerdOliver GruberDiana Tordesillas GutiérrezPatricia GrunerRachel E GurPascual Sánchez JuanRuben C GurBen J HarrisonCatharine A HartmanSean N HattonYannis PaloyelisHenk S TemminghIrina LebedevaNancy C AndreasenLuisa LázaroAndreas HeinzEsther WaltonFleur M HowellsSalvador SarróHilleke E Hulshoff PolChaim HuyserNeda JahanshadBernd WeberAnthony JamesAndrew M McintoshTerry L JerniganSophia I ThomopoulosJiyang JiangErik G JönssonJohn A JoskaRene KahnTheodore D SatterthwaiteLei WangWon Hee LeePaul PauliAndrew J SaykinAndrew KalninRyota KanaiMicael AnderssonKlaus Peter LeschAlexander S TomyshevChristine LochnerMarise W. J MachielsenSophie MaingaultTobias BanaschewskiNicholas G MartinJessica A TurnerGiulio PergolaIgnacio Martínez ZalacaínLaura KoendersKatie L McMahonGenevieve McPhilemyJosé Manuel Menchón MagriñáSarah E MedlandThomas H WassinkAndreas Meyer LindenbergJilly NaaijenPablo NajtJulian N TrollorTomohiro NakaoJan K BuitelaarJohn D WestMauricio H SerpaJan E NordvikBenedicto Crespo FacorroEdith Pomarol ClotetMaria J PortellaSteven G PotkinJoaquim RaduaPhilip AshersonAndreas ReifGeraldo F BusattoDaniel A RinkerJoshua L RoffmanWei WenPedro G. P RosaFabrice CrivelloSarah BaumeisterAnne UhlmannMatthew D SacchetSimon E FisherLianne SchmaalRandy L BucknerKnut SchnellGunter SchumannKang SimJordan W SmollerIris SommerEveline A CroneCarles Soriano MasDan J SteinNúria Bargalló AlabartLachlan T StrikeVincent CalhounJean Paul FoucheHeather WhalleyLars T WestlyeSuzanne C SwagermanDirk J HeslenfeldOdile A HeuvelAnders M DaleDennis MeerNic J. A WeeNeeltje E. M HarenPieter J HoekstraDennis EntTheo G. M ErpBarbara FrankeIlya M VeerDick J VeltmanAristotle VoineskosHenry VölzkeChristopher DaveyDerrek P HibarAlessandro BertolinoErick J Canales RodríguezRamona Baur StreubelHenrik WalterMarieke KleinLara M WierengaThomas FrodlKatharina WittfeldDaniel H WolfAmanda WorkerBernd KrämerMargaret J WrightDara M CannonKun Yang
- Resource Type
- Journal article
- Publication Details
- Human brain mapping, Vol.43(1), pp.431-451
- DOI
- 10.1002/hbm.25364
- PMID
- 33595143
- PMCID
- PMC8675431
- NLM abbreviation
- Hum Brain Mapp
- ISSN
- 1065-9471
- eISSN
- 1097-0193
- Publisher
- Wiley
- Grant note
- DOI: 10.13039/100000097, name: National Center for Research Resources, award: RR025761; DOI: 10.13039/501100001826, name: ZonMw, award: 480‐15‐001/674, 024.001.003, 911‐09‐032, 056‐32‐010, 481‐08‐011, 016‐115‐035, 31160008, 400‐07‐080, 400‐05‐717, 451‐04‐034, 463‐06‐001, 480‐04‐004, 904‐61‐193, 912‐10‐020, 985‐10‐002, 904‐61‐090; DOI: 10.13039/100000025, name: National Institute of Mental Health, award: R01 MH090553; DOI: 10.13039/100011199, name: FP7 Ideas: European Research Council; DOI: 10.13039/501100003246, name: Nederlandse Organisatie voor Wetenschappelijk Onderzoek, award: NWO/SPI 56‐464‐14192, NWO‐MagW 480‐04‐004, 433‐09‐220, NWO 51.02.062, NWO 51.02.061; DOI: 10.13039/100000097, name: National Center for Research Resources; DOI: 10.13039/501100007155, name: Medical Research Council Canada, award: U54EB020403, G0500092; DOI: 10.13039/100000025, name: National Institute of Mental Health, award: R01MH117014, R01MH042191; DOI: 10.13039/501100004587, name: Instituto de Salud Carlos III, award: PI14/00918, PI14/00639, PI060507, PI050427, PI020499; DOI: 10.13039/501100004359, name: Vetenskapsrådet, award: 523‐2014‐3467, 2017‐00949, 521‐2014‐3487; DOI: 10.13039/100007277, name: Icahn School of Medicine at Mount Sinai; DOI: 10.13039/100011102, name: Seventh Framework Programme, award: 602450; DOI: 10.13039/100000002, name: National Institutes of Health, award: R01 MH116147, R01 MH113619, R01 MH104284; DOI: 10.13039/100009362, name: South London and Maudsley NHS Foundation Trust
- Language
- English
- Electronic publication date
- 02/17/2021
- Academic Unit
- Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
- Record Identifier
- 9984068336402771
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