Journal article
Cortico-subcortical β burst dynamics underlying movement cancellation in humans
eLife, Vol.10, e70270
12/07/2021
DOI: 10.7554/eLife.70270
PMCID: PMC8691838
PMID: 34874267
Abstract
Dominant neuroanatomical models hold that humans regulate their movements via loop-like cortico-subcortical networks, which include the subthalamic nucleus (STN), motor thalamus, and sensorimotor cortex (SMC). Inhibitory commands across these networks are purportedly sent via transient, burst-like signals in the β frequency (15-29Hz). However, since human depth-recording studies are typically limited to one recording site, direct evidence for this proposition is hitherto lacking. Here, we present simultaneous multi-site recordings from SMC and either STN or motor thalamus in humans performing the stop-signal task. In line with their purported function as inhibitory signals, subcortical β-bursts were increased on successful stop-trials. STN bursts in particular were followed within 50ms by increased β-bursting over SMC. Moreover, between-site comparisons (including in a patient with simultaneous recordings from SMC, thalamus, and STN) confirmed that β-bursts in STN temporally precede thalamic β-bursts. This highly unique set of recordings provides empirical evidence for the role of β-bursts in conveying inhibitory commands along long-proposed cortico-subcortical networks underlying movement regulation in humans.
Details
- Title: Subtitle
- Cortico-subcortical β burst dynamics underlying movement cancellation in humans
- Creators
- Darcy A DiesburgJeremy DW GreenleeJan R Wessel
- Resource Type
- Journal article
- Publication Details
- eLife, Vol.10, e70270
- DOI
- 10.7554/eLife.70270
- PMID
- 34874267
- PMCID
- PMC8691838
- NLM abbreviation
- Elife
- ISSN
- 2050-084X
- eISSN
- 2050-084X
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: T32GM108540; DOI: 10.13039/100000002, name: National Institutes of Health, award: R01NS117753; DOI: 10.13039/100000001, name: National Science Foundation, award: CAREER 1752355; name: Carver College of Medicine & Iowa Neuroscience Institute, award: Research Program of Excellence Funding
- Language
- English
- Date published
- 12/07/2021
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Stead Family Department of Pediatrics; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
- Record Identifier
- 9984201558402771
Metrics
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