Journal article
Corticosterone accelerates atherosclerosis in the apolipoprotein E-deficient mouse
Atherosclerosis, Vol.232(2), pp.414-419
02/01/2014
DOI: 10.1016/j.atherosclerosis.2013.11.076
PMID: 24468157
Abstract
Chronic stress is an important risk factor for atherosclerosis, which is a chief process in the development of cardiovascular disease. Increased circulating levels of corticosterone have been documented in several animal models of chronic stress. However, it remains to be established whether corticosterone is sufficient to exacerbate atherosclerosis. To test this hypothesis, apolipoprotein E (ApoE)-deficient mice were fed a high-fat diet for 13 weeks with exposure to either corticosterone or vehicle in the drinking water (CORT and Con). Corticosterone treatment significantly increased atherosclerotic plaque area at the aortic root. Such exacerbation of atherosclerosis was accompanied by significantly lower levels of circulating white blood cells and serum interleukin-1 beta (IL-1 beta), and significantly elevated serum concentrations of total cholesterol, low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL) and small dense low-density lipoprotein (sd-LDL) in CORT mice when compared to Con mice. These findings demonstrate that corticosterone is sufficient to exacerbate atherosclerosis in vivo despite its anti-inflammatory properties and that this marked pro-atherogenic phenotype is primarily associated with increased dyslipidaemia. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
Details
- Title: Subtitle
- Corticosterone accelerates atherosclerosis in the apolipoprotein E-deficient mouse
- Creators
- Mitsuharu Okutsu - Waseda UniversityVitor A. Lira - University of IowaKazuhiko Higashida - Waseda UniversityJonathan Peake - Queensland University of TechnologyMitsuru Higuchi - Waseda UniversityKatsuhiko Suzuki - Waseda University
- Resource Type
- Journal article
- Publication Details
- Atherosclerosis, Vol.232(2), pp.414-419
- Publisher
- Elsevier
- DOI
- 10.1016/j.atherosclerosis.2013.11.076
- PMID
- 24468157
- ISSN
- 0021-9150
- eISSN
- 1879-1484
- Number of pages
- 6
- Grant note
- DOI: 10.13039/501100001700, name: Ministry of Education, Culture, Sports, Science and Technology, award: 18700563
- Language
- English
- Date published
- 02/01/2014
- Academic Unit
- Health and Human Physiology
- Record Identifier
- 9984259657102771
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