Cortisol awakening response and developmental outcomes at 6–7 years in children born extremely preterm

Alan H Jobe; Heidi M Harmon; Michael S Caplan; Richard A Polin; Abbot R Laptook; Angelita M Hensman; Elisa Vieira; Emilee Little; Katharine Johnson; Barbara Alksninis; Mary Lenore Keszler; Andrea M Knoll; Theresa M Leach; Elisabeth C McGowan; Victoria E Watson; Michele C Walsh; Avroy A Fanaroff; Allison Payne; Deanne E Wilson-Costello; Nancy S Newman; Bonnie S Siner; Arlene Zadell; Julie DiFiore; Monika Bhola; Harriet G Friedman; Gulgun Yalcinkaya; Ronald N Goldberg; C Michael Cotten; Kathryn E Gustafson; Ricki F Goldstein; Patricia Ashley; Kathy J Auten; Kimberley A Fisher; Katherine A Foy; Sharon F Freedman; Melody B Lohmeyer; William F Malcolm; David K Wallace; David P Carlton; Barbara J Stoll; Ira Adams-Chapman; Susie Buchter; Anthony J Piazza; Sheena Carter; Sobha Fritz; Ellen C Hale; Amy K Hutchinson; Maureen Mulligan LaRossa; Yvonne Loggins; Diane Bottcher; Rosemary D Higgins; Stephanie Wilson Archer; Brenda B Poindexter; Gregory M Sokol; Lu-Ann Papile; Abbey C Hines; Leslie D Wilson; Dianne E Herron; Lucy Smiley; Douglas A Granger; Kathleen A Kennedy; Jon E Tyson; Andrea F Duncan; Allison G Dempsey; Janice John; Patrick M Jones; M Layne Lillie; Saba Siddiki; Daniel K Sperry; Carol J Blaisdell; Abhik Das; Dennis Wallace; Marie G Gantz; Jeanette O’Donnell Auman; Jane A Hammond; Jamie E Newman; W Kenneth Poole; Krisa P Van Meurs; David K Stevenson; M Bethany Ball; Maria Elena DeAnda; Gabrielle T Goodlin; Ivan D Frantz; John M Fiascone; Anne Kurfiss; Brenda L MacKinnon; Ellen Nylen; Ana Brussa; Cecelia Sibley; Waldemar A Carlo; Namasivayam Ambalavanan; Monica V Collins; Shirley S Cosby; Vivien A Phillips; Kristy Domanovich; Sally Whitley; Leigh Ann Smith; Carin R Kiser; Neil N Finer; SUPPORT NEURO School-Age Study Subcommittee of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network; Edward F Bell; Tarah T Colaizy; John A Widness; Jonathan M Klein; Karen J Johnson; Michael J. Acarregui; Diane L Eastman; Tammy L V Wilgenbusch

doi:10.1038/s41390-022-02113-9

Journal article

Cortisol awakening response and developmental outcomes at 6–7 years in children born extremely preterm

Alan H Jobe, Heidi M Harmon, Michael S Caplan, Richard A Polin, Abbot R Laptook, Angelita M Hensman, Elisa Vieira, Emilee Little, Katharine Johnson, Barbara Alksninis, …

Pediatric Research, Vol.93(3), pp.689-695

02/01/2023

DOI: 10.1038/s41390-022-02113-9

PMCID: PMC9758271

PMID: 35715492

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Abstract

Background Extremely preterm (EPT) birth has been related to dysregulation of stress responses and behavioral/learning problems at school age. Early adverse experiences can blunt HPA axis reactivity. We hypothesized that an attenuated cortisol awakening response would be associated with developmental and behavioral problems at school age in EPT children. Methods This secondary analysis of a sub-cohort of the SUPPORT study included children born between 24 and 27 weeks, evaluated at 6-7 years with a neurodevelopmental battery and cortisol measures. Differences were tested between EPT and a term-born group. Relationships of cortisol awakening response to test scores were analyzed. Results Cortisol was measured in 110 EPT and 29 term-born 6-7 year olds. Unadjusted WISC-IV and NEPSY-II scores were significantly worse among EPT children only. Conners Parent Rating Scale behavior scores were significantly worse among EPT children. After adjusting for covariates, blunted cortisol awakening responses were found to be associated with poorer scores on memory tests and greater problems with inattention for the EPT group (p < 0.05) only.Conclusions Among children born EPT, we identified an association of blunted cortisol awakening response with memory and inattention problems. This may have implications related to stress reactivity and its relationship to learning problems in children born EPT.ClinicaltrialsGov idExtended Follow-up at School Age for the SUPPORT Neuroimaging and Neurodevelopmental Outcomes (NEURO) Cohort: NCT00233324.ImpactIn children born EPT, stress reactivity may have a relationship to learning problems. Cortisol awakening response should be a component for follow-up in EPT born children. Components of executive function, such as memory and attention, are related to stress reactivity.

Mental Health

Pediatrics

2.3 Psychological

Aetiology

Basic Behavioral and Social Science

Behavioral and Social Science

Biomedical and Clinical Sciences

Child

Clinical Research

Executive Function

Extremely Premature

Female

Humans

Hydrocortisone

Hypothalamo-Hypophyseal System

Infant

Mind and Body

Neurosciences

Newborn

Paediatrics

Paediatrics and Reproductive Medicine

Pediatric

Pituitary-Adrenal System

Public Health and Health Services

social and economic factors

SUPPORT NEURO School-Age Study Subcommittee of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

Details

Title: Subtitle: Cortisol awakening response and developmental outcomes at 6–7 years in children born extremely preterm
Creators: Alan H Jobe
Heidi M Harmon
Michael S Caplan
Richard A Polin
Abbot R Laptook
Angelita M Hensman
Elisa Vieira
Emilee Little
Katharine Johnson
Barbara Alksninis
Mary Lenore Keszler
Andrea M Knoll
Theresa M Leach
Elisabeth C McGowan
Victoria E Watson
Michele C Walsh
Avroy A Fanaroff
Allison Payne
Deanne E Wilson-Costello
Nancy S Newman
Bonnie S Siner
Arlene Zadell
Julie DiFiore
Monika Bhola
Harriet G Friedman
Gulgun Yalcinkaya
Ronald N Goldberg
C Michael Cotten
Kathryn E Gustafson
Ricki F Goldstein
Patricia Ashley
Kathy J Auten
Kimberley A Fisher
Katherine A Foy
Sharon F Freedman
Melody B Lohmeyer
William F Malcolm
David K Wallace
David P Carlton
Barbara J Stoll
Ira Adams-Chapman
Susie Buchter
Anthony J Piazza
Sheena Carter
Sobha Fritz
Ellen C Hale
Amy K Hutchinson
Maureen Mulligan LaRossa
Yvonne Loggins
Diane Bottcher
Rosemary D Higgins
Stephanie Wilson Archer
Brenda B Poindexter
Gregory M Sokol
Lu-Ann Papile
Abbey C Hines
Leslie D Wilson
Dianne E Herron
Lucy Smiley
Douglas A Granger
Kathleen A Kennedy
Jon E Tyson
Andrea F Duncan
Allison G Dempsey
Janice John
Patrick M Jones
M Layne Lillie
Saba Siddiki
Daniel K Sperry
Carol J Blaisdell
Abhik Das
Dennis Wallace
Marie G Gantz
Jeanette O’Donnell Auman
Jane A Hammond
Jamie E Newman
W Kenneth Poole
Krisa P Van Meurs
David K Stevenson
M Bethany Ball
Maria Elena DeAnda
Gabrielle T Goodlin
Ivan D Frantz
John M Fiascone
Anne Kurfiss
Brenda L MacKinnon
Ellen Nylen
Ana Brussa
Cecelia Sibley
Waldemar A Carlo
Namasivayam Ambalavanan
Monica V Collins
Shirley S Cosby
Vivien A Phillips
Kristy Domanovich
Sally Whitley
Leigh Ann Smith
Carin R Kiser
Neil N Finer
SUPPORT NEURO School-Age Study Subcommittee of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Edward F Bell (Contributor) - University of Iowa, Neonatology
Tarah T Colaizy (Contributor) - University of Iowa, Neonatology
John A Widness (Contributor) - University of Iowa, Stead Family Department of Pediatrics
Jonathan M Klein (Contributor) - University of Iowa, Neonatology
Karen J Johnson (Contributor) - University of Iowa
Michael J. Acarregui (Contributor) - University of Iowa
Diane L Eastman (Contributor) - University of Iowa
Tammy L V Wilgenbusch (Contributor) - University of Iowa, Developmental and Behavioral Pediatrics
Resource Type: Journal article
Publication Details: Pediatric Research, Vol.93(3), pp.689-695
DOI: 10.1038/s41390-022-02113-9
PMID: 35715492
PMCID: PMC9758271
NLM abbreviation: Pediatr Res
ISSN: 0031-3998
eISSN: 1530-0447
Publisher: Springer
Number of pages: 689 - 695
Language: English
Date published: 02/01/2023
Academic Unit: Pediatric Psychology; Stead Family Department of Pediatrics; Neonatology
Record Identifier: 9984639658702771

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