Journal article
Cortistatin modulates memory evocation in rats
European journal of pharmacology, Vol.507(1), pp.21-28
01/10/2005
DOI: 10.1016/j.ejphar.2004.10.054
PMID: 15659290
Abstract
The neurochemical control of learning depends on several neurotransmitters, hormones, and neuropeptides. Cortistatin is a neuropeptide with sleep-modulating properties that regulates memory consolidation and evocation. Several reports have suggested that learning processes are expressed under diurnal variations; therefore, it seems that the efficiency to solve learning tasks is related to the arousal state. Although we know that cortistatin modulates learning, we do not know whether its effect is subjected to diurnal variations. Hence, we evaluated memory evocation and the sleep–waking cycle along the day. Additionally, we evaluated the effect of cortistatin on motor control and cyclic adenosine monophosphate (cAMP) concentration. Performance of rats was better at 01:00 h than at 13:00 h to solve the Barnes maze. Cortistatin impaired memory evocation, increased rapid-eye-movement (REM) sleep, and decreased wakefulness at 01:00 h, whereas increasing it at 13:00 h. Cortistatin blunts cAMP concentration and impairs motor control at 13:00 h. These results support further a cortistatin modulatory role in the memory process.
Details
- Title: Subtitle
- Cortistatin modulates memory evocation in rats
- Creators
- Mónica Méndez-Díaz - Universidad Nacional Autónoma de MéxicoLouis Irwin - Department of Biological Sciences, The University of Texas, El Paso, El Paso TX, USAMargarita Gómez-Chavarín - Universidad Nacional Autónoma de MéxicoAnabel Jiménez-Anguiano - Universidad Autónoma MetropolitanaRafael Cabeza - Department of Biological SciencesEric Murillo-Rodríguez - Universidad Nacional Autónoma de MéxicoOscar Prospéro-García - Universidad Nacional Autónoma de México
- Resource Type
- Journal article
- Publication Details
- European journal of pharmacology, Vol.507(1), pp.21-28
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.ejphar.2004.10.054
- PMID
- 15659290
- ISSN
- 0014-2999
- eISSN
- 1879-0712
- Language
- English
- Date published
- 01/10/2005
- Academic Unit
- Molecular Physiology and Biophysics
- Record Identifier
- 9984695682602771
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