Costs of achieving live birth from assisted reproductive technology: a comparison of sequential single and double embryo transfer approaches

Sara Crawford; Sheree L. Boulet; Allison S. Mneimneh; Kiran M. Perkins; Denise J. Jamieson; Yujia Zhang; Dmitry M. Kissin

doi:10.1016/j.fertnstert.2015.10.032

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Costs of achieving live birth from assisted reproductive technology: a comparison of sequential single and double embryo transfer approaches

Journal article

Open access

Peer reviewed

Costs of achieving live birth from assisted reproductive technology: a comparison of sequential single and double embryo transfer approaches

Sara Crawford, Sheree L. Boulet, Allison S. Mneimneh, Kiran M. Perkins, Denise J. Jamieson, Yujia Zhang and Dmitry M. Kissin

Fertility and sterility, Vol.105(2), pp.444-450

02/01/2016

DOI: 10.1016/j.fertnstert.2015.10.032

PMCID: PMC5125029

PMID: 26604068

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Abstract

Objective: To assess treatment and pregnancy/infant-associated medical costs and birth outcomes for assisted reproductive technology (ART) cycles in a subset of patients using elective double embryo (ET) and to project the difference in costs and outcomes had the cycles instead been sequential single ETs (fresh followed by frozen if the fresh ET did not result in live birth). Design: Retrospective cohort study using 2012 and 2013 data from the National ART Surveillance System. Setting: Infertility treatment centers. Patient(s): Fresh, autologous double ETs performed in 2012 among ART patients younger than 35 years of age with no prior ART use who cryopreserved at least one embryo. Intervention(s): Sequential single and double ETs. Main Outcome Measure(s): Actual live birth rates and estimated ART treatment and pregnancy/infant-associated medical costs for double ET cycles started in 2012 and projected ART treatment and pregnancy/infant-associated medical costs if the double ET cycles had been performed as sequential single ETs. Result(s): The estimated total ART treatment and pregnancy/infant-associated medical costs were $ 580.9 million for 10,001 double ETs started in 2012. If performed as sequential single ETs, estimated costs would have decreased by $ 195.0 million to $ 386.0 million, and live birth rates would have increased from 57.7%-68.0%. Conclusion(s): Sequential single ETs, when clinically appropriate, can reduce total ART treatment and pregnancy/infant-associated medical costs by reducing multiple births without lowering live birth rates. (C) 2016 by American Society for Reproductive Medicine.

Life Sciences & Biomedicine

Obstetrics & Gynecology

Reproductive Biology

Science & Technology

Details

Title: Subtitle: Costs of achieving live birth from assisted reproductive technology: a comparison of sequential single and double embryo transfer approaches
Creators: Sara Crawford - National Center for Chronic Disease Prevention and Health Promotion
Sheree L. Boulet - National Center for Chronic Disease Prevention and Health Promotion
Allison S. Mneimneh - National Center for Chronic Disease Prevention and Health Promotion
Kiran M. Perkins - National Center for Chronic Disease Prevention and Health Promotion
Denise J. Jamieson - National Center for Chronic Disease Prevention and Health Promotion
Yujia Zhang - National Center for Chronic Disease Prevention and Health Promotion
Dmitry M. Kissin - Centers for Disease Control and Prevention
Resource Type: Journal article
Publication Details: Fertility and sterility, Vol.105(2), pp.444-450
DOI: 10.1016/j.fertnstert.2015.10.032
PMID: 26604068
PMCID: PMC5125029
NLM abbreviation: Fertil Steril
ISSN: 0015-0282
eISSN: 1556-5653
Publisher: Elsevier
Number of pages: 7
Grant note: CC999999 / Intramural CDC HHS
Language: English
Date published: 02/01/2016
Academic Unit: Obstetrics and Gynecology; VPMA - Administration
Record Identifier: 9984446437702771

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