Journal article
Cotton-Wool Spots (Inner Retinal Ischemic Spots) in Malignant Arterial Hypertension
Ophthalmologica (Basel), Vol.198(4), pp.197-215
1989
DOI: 10.1159/000309999
PMID: 2748098
Abstract
We produced experimental renovascular malignant arterial hypertension by modified Goldblatt's procedures, in 60 rhesus monkeys. Hypertensive retinopathy was studied in detail (by ophthalmoscopy, and stereoscopic color fundus photography and fluorescein fundus angiography on long-term follow-up). Cotton-wool spots (CWSs) were found to be an important, early retinal lesion. On ophthalmoscopy, they had a characteristic appearance. Fluorescein fundus angiography of these lesions revealed focal retinal capillary nonperfusion. The CWSs usually lasted for over 3 weeks and resolved within 6 weeks, leaving permanent obliteration of the retinal capillaries in their distribution, secondary intraretinal microvascular abnormalities, and retinal nerve fiber loss. We discuss pathogenesis and other features of CWSs. There is overwhelming evidence that CWSs are due to occlusion of the terminal retinal arterioles, resulting in acute focal inner retinal ischemia; hence the scientifically valid term for them would be 'inner retinal ischemic spots'.
Details
- Title: Subtitle
- Cotton-Wool Spots (Inner Retinal Ischemic Spots) in Malignant Arterial Hypertension
- Creators
- Sohan Singh Hayreh - University of IowaGary E ServaisPrem Singh Virdi
- Resource Type
- Journal article
- Publication Details
- Ophthalmologica (Basel), Vol.198(4), pp.197-215
- DOI
- 10.1159/000309999
- PMID
- 2748098
- eISBN
- 9783318056488; 3318056480
- ISSN
- 0030-3755
- eISSN
- 1423-0267
- Number of pages
- 19
- Language
- English
- Date published
- 1989
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9984182975502771
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