Journal article
Course of treatment received by depressed patients
Journal of psychiatric research, Vol.33(3), pp.233-242
1999
DOI: 10.1016/S0022-3956(98)00055-7
PMID: 10367989
Abstract
Using data from an observational study of affective disorders, we describe the rates of transition among levels of antidepressant treatment for subjects with Major Depressive Disorder (MDD), and relate these changes to changes in clinical status. We report on the treatment received during the first 10 years of follow-up in the Collaborative Depression Study by 555 patients with a diagnosis of MDD of at least one months duration. This work extends the initial examination of treatment received during the first eight weeks after entry into this study that showed depressed patients to be on low levels of treatment. Multiplicative intensity models which generalize survival analysis models were used to analyse these data. Description of the course of treatment of these depressed patients shows that low levels of treatment persist for these patients across subsequent episodes, and that these episodes, like the index one, are characterized by extended time in a symptomatic subcriterion state after acute symptoms have improved. These long-term descriptions of treatment support the initial hypothesis that these CDS patients were undertreated. The long-term tendency toward undertreatment seems to persist even as newer treatments become available and widely accepted in practice.
Details
- Title: Subtitle
- Course of treatment received by depressed patients
- Creators
- R Dawson - Frontier Science and Technology Research Foundation, MA 02167, USAP.W Lavori - Frontier Science and Technology Research Foundation, MA 02167, USAW.H Coryell - University of Iowa College of Medicine, Psychiatry Research, Iowa City, USAJ Endicott - NYS Psychiatric Institute, New York, USAM.B Keller - School of Medicine, Department of Psychiatry and Human Behavior, Brown University, Providence, USA
- Resource Type
- Journal article
- Publication Details
- Journal of psychiatric research, Vol.33(3), pp.233-242
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/S0022-3956(98)00055-7
- PMID
- 10367989
- ISSN
- 0022-3956
- eISSN
- 1879-1379
- Language
- English
- Date published
- 1999
- Academic Unit
- Psychiatry
- Record Identifier
- 9984004091702771
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