Journal article
Covarying structural alterations in laterality of the temporal lobe in schizophrenia: A case for source‐based laterality
NMR in biomedicine, Vol.33(6), pp.e4294-n/a
06/2020
DOI: 10.1002/nbm.4294
PMCID: PMC8311554
PMID: 32207187
Abstract
The human brain is asymmetrically lateralized for certain functions (such as language processing) to regions in one hemisphere relative to the other. Asymmetries are measured with a laterality index (LI). However, traditional LI measures are limited by a lack of consensus on metrics used for its calculation. To address this limitation, source‐based laterality (SBL) leverages an independent component analysis for the identification of laterality‐specific alterations, identifying covarying components between hemispheres across subjects. SBL is successfully implemented with simulated data with inherent differences in laterality. SBL is then compared with a voxel‐wise analysis utilizing structural data from a sample of patients with schizophrenia and controls without schizophrenia. SBL group comparisons identified three distinct temporal regions and one cerebellar region with significantly altered laterality in patients with schizophrenia relative to controls. Previous work highlights reductions in laterality (ie, reduced left gray matter volume) in patients with schizophrenia compared with controls without schizophrenia. Results from this pilot SBL project are the first, to our knowledge, to identify covarying laterality differences within discrete temporal brain regions. The authors argue SBL provides a unique focus to detect covarying laterality differences in patients with schizophrenia, facilitating the discovery of laterality aspects undetected in previous work.
By subtracting of gray matter maps from opposing hemispheres of the brain, independent component analysis of structural imaging data may identify covarying components across hemispheres, designated as source‐based laterality. The loading coefficients from components can then be utilized to assess hemispheric differences between brain regions. Comparing laterality‐based components between participants with and without schizophrenia revealed three temporal and one cerebellar region where brain volume is altered across hemispheres.
Details
- Title: Subtitle
- Covarying structural alterations in laterality of the temporal lobe in schizophrenia: A case for source‐based laterality
- Creators
- Thomas P DeRamus - Georgia State University, Georgia Institute of Technology, Emory UniversityRogers F Silva - Georgia State University, Georgia Institute of Technology, Emory UniversityArmin Iraji - Georgia State University, Georgia Institute of Technology, Emory UniversityEswar Damaraju - Georgia State University, Georgia Institute of Technology, Emory UniversityAysenil Belger - University of North Carolina Chapel HillJudith M Ford - University of California San FranciscoSarah C McEwen - Pacific Neuroscience Institute FoundationDaniel H Mathalon - University of California San FranciscoBryon A Mueller - University of MinnesotaGodfrey D Pearlson - Institute of LivingSteven G Potkin - University of California IrvineAdrian Preda - University of California IrvineJessica A Turner - Georgia State UniversityJatin G Vaidya - University of IowaTheo G. M Erp - University of California IrvineVince D Calhoun - Georgia Tech
- Resource Type
- Journal article
- Publication Details
- NMR in biomedicine, Vol.33(6), pp.e4294-n/a
- DOI
- 10.1002/nbm.4294
- PMID
- 32207187
- PMCID
- PMC8311554
- NLM abbreviation
- NMR Biomed
- ISSN
- 0952-3480
- eISSN
- 1099-1492
- Number of pages
- 16
- Grant note
- National Institute of General Medical Sciences (P20GM103472; P30GM122734) National Science Foundation (1539067) National Institute of Biomedical Imaging and Bioengineering (R01EB006841; R01EB020407) National Institute of Mental Health (R01MH094524)
- Language
- English
- Date published
- 06/2020
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute; University College Courses
- Record Identifier
- 9984070013202771
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