Covid-19 vaccination in pregnancy

Martina L Badell; Carolynn M Dude; Sonja A Rasmussen; Denise J Jamieson

doi:10.1136/bmj-2021-069741

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Journal article

Open access

Peer reviewed

Covid-19 vaccination in pregnancy

Martina L Badell, Carolynn M Dude, Sonja A Rasmussen and Denise J Jamieson

BMJ (Online), Vol.378, pp.e069741-e069741

08/10/2022

DOI: 10.1136/bmj-2021-069741

PMCID: PMC9363819

PMID: 35948352

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Abstract

ABSTRACTPregnancy is an independent risk factor for severe covid-19. Vaccination is the best way to reduce the risk for SARS-CoV-2 infection and limit its morbidity and mortality. The current recommendations from the World Health Organization, Centers for Disease Control and Prevention, and professional organizations are for pregnant, postpartum, and lactating women to receive covid-19 vaccination. Pregnancy specific considerations involve potential effects of vaccination on fetal development, placental transfer of antibodies, and safety of maternal vaccination. Although pregnancy was an exclusion criterion in initial clinical trials of covid-19 vaccines, observational data have been rapidly accumulating and thus far confirm that the benefits of vaccination outweigh the potential risks. This review examines the evidence supporting the effectiveness, immunogenicity, placental transfer, side effects, and perinatal outcomes of maternal covid-19 vaccination. Additionally, it describes factors associated with vaccine hesitancy in pregnancy. Overall, studies monitoring people who have received covid-19 vaccines during pregnancy have not identified any pregnancy specific safety concerns. Additional information on non-mRNA vaccines, vaccination early in pregnancy, and longer term outcomes in infants are needed. To collect this information, vaccination during pregnancy must be prioritized in vaccine research.

Clinical Review

Details

Title: Subtitle: Covid-19 vaccination in pregnancy
Creators: Martina L Badell - Emory University
Carolynn M Dude - Emory University
Sonja A Rasmussen - University of Florida
Denise J Jamieson - Emory University
Resource Type: Journal article
Publication Details: BMJ (Online), Vol.378, pp.e069741-e069741
Publisher: British Medical Journal Publishing Group
DOI: 10.1136/bmj-2021-069741
PMID: 35948352
PMCID: PMC9363819
ISSN: 0959-535X
eISSN: 1756-1833
Language: English
Date published: 08/10/2022
Academic Unit: Obstetrics and Gynecology; VPMA - Administration
Record Identifier: 9984446400502771

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