Journal article
Coxsackievirus Genome in Myocardium of Patients with Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
Cardiology, Vol.89(4), pp.241-245
05/1998
DOI: 10.1159/000006794
PMID: 9643269
Abstract
Enteroviruses are known as major infectious agents for inflammatory heart diseases such as myocarditis and dilated cardiomyopathy (DCM). Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVC) is characterized by replacement of right ventricular myocardium by fatty and fibrous tissue. In about 65% of patients inflammatory infiltrates suggest an inflammatory or infectious etiopathogenesis. To test this hypothesis, we investigated endomyocardial biopsies of patients with ARVC, with myocarditis or DCM, and from patients with non-inflammatory cardiac disorders for the presence of enteroviral genome. Enteroviral RNA with homology to coxsackieviruses type B was detected in 3 of 8 patients with ARVC (37.5%), in 7 of 23 patients with myocarditis or DCM (30.4%), but in none of 5 patient with non-infectious myocardial diseases (p < 0.05 compared to ARVC patients). These results support earlier suggestions that coxsackievirus infection of the myocardium is possibly related to the pathogenesis of ARVC.
Details
- Title: Subtitle
- Coxsackievirus Genome in Myocardium of Patients with Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
- Creators
- Isabella M GrumbachAlbert HeimStefan VonhofMichael Stille-SiegenerGerhard MallBernd D GonskaHeinrich KreuzerStefan AndreasHans R Figulla
- Resource Type
- Journal article
- Publication Details
- Cardiology, Vol.89(4), pp.241-245
- DOI
- 10.1159/000006794
- PMID
- 9643269
- ISSN
- 0008-6312
- eISSN
- 1421-9751
- Number of pages
- 5
- Language
- English
- Date published
- 05/1998
- Academic Unit
- Cardiovascular Medicine; Radiation Oncology; Internal Medicine
- Record Identifier
- 9984094342802771
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