Cranial osteomyelitis: diagnosis and follow-up with In-111 white blood cell and Tc-99m methylene diphosphonate bone SPECT, CT, and MR imaging

J E Seabold; T M Simonson; P C Weber; B H Thompson; K G Harris; K Rezai; M T Madsen; H T Hoffman

doi:10.1148/radiology.196.3.7644643

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Cranial osteomyelitis: diagnosis and follow-up with In-111 white blood cell and Tc-99m methylene diphosphonate bone SPECT, CT, and MR imaging

Journal article

Peer reviewed

Cranial osteomyelitis: diagnosis and follow-up with In-111 white blood cell and Tc-99m methylene diphosphonate bone SPECT, CT, and MR imaging

J E Seabold, T M Simonson, P C Weber, B H Thompson, K G Harris, K Rezai, M T Madsen and H T Hoffman

Radiology, Vol.196(3), pp.779-788

09/1995

DOI: 10.1148/radiology.196.3.7644643

PMID: 7644643

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Abstract

To assess the usefulness of indium-111 white blood cell and technetium-99m methylene diphosphonate bone single photon emission computed tomography (SPECT), computed tomography (CT), and magnetic resonance (MR) imaging in cranial osteomyelitis. Twenty-six cases (25 patients: 13 male, 12 female; mean age, 55 years) of suspected osteomyelitis were evaluated. Sixteen were postoperative. Final diagnosis was established by means of bone culture in 18 cases and clinical follow-up in eight. Of 35 CT scans, 10 were true-positive (TP); three false-negative (FN); 13, true-negative (TN); one, false-positive (FP); and eight, equivocal. Of 36 SPECT scans, 19 were TP; 13, TN; one, FP; one, FN; and two, equivocal. Of 11 MR images four were TP; five, TN; and two, FN. CT is best for differentiation between soft-tissue and bone infection. MR imaging is best for assessment of the calvaria and skull base. SPECT is best for assessment of altered bone and may be the best technique for follow-up.

Magnetic Resonance Imaging

Jaw Diseases - diagnosis

Technetium Tc 99m Medronate

Follow-Up Studies

Humans

Middle Aged

Tomography, Emission-Computed, Single-Photon

Male

Tomography, X-Ray Computed

Leukocytes

Osteomyelitis - diagnostic imaging

Jaw Diseases - pathology

Skull - pathology

Osteomyelitis - pathology

Sensitivity and Specificity

Adult

Female

Retrospective Studies

Cells, Cultured

Osteomyelitis - diagnosis

Biopsy

Skull - diagnostic imaging

Adolescent

Aged

Jaw Diseases - diagnostic imaging

Indium Radioisotopes

Details

Title: Subtitle: Cranial osteomyelitis: diagnosis and follow-up with In-111 white blood cell and Tc-99m methylene diphosphonate bone SPECT, CT, and MR imaging
Creators: J E Seabold - Department of Radiology, University of Iowa College of Medicine, Iowa City, USA
T M Simonson
P C Weber
B H Thompson
K G Harris
K Rezai
M T Madsen
H T Hoffman
Resource Type: Journal article
Publication Details: Radiology, Vol.196(3), pp.779-788
Publisher: United States
DOI: 10.1148/radiology.196.3.7644643
PMID: 7644643
ISSN: 0033-8419
eISSN: 1527-1315
Language: English
Date published: 09/1995
Academic Unit: Radiology; Radiation Oncology; Otolaryngology
Record Identifier: 9984006403202771

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