Journal article
Craniosynostosis and maternal smoking
Birth Defects Research Part A: Clinical and Molecular Teratology, Vol.66(2), pp.78-85
02/2008
DOI: 10.1002/bdra.20426
PMID: 18050313
Abstract
BACKGROUND: Several previous studies suggested increased risk of craniosynostosis among infants born to women who smoked. METHODS: This study used data from the National Birth Defects Prevention Study, a multi-state, population-based case-control study of infants delivered from 1997–2003. Nonmalformed, liveborn controls were selected randomly from birth certificates or birth hospitals. Data from maternal telephone interviews were available for 531 cases and 5008 controls. RESULTS: Smoking during the first month of pregnancy was not associated with craniosynostosis. Smoking later in pregnancy was associated with increased risk, but only among mothers who smoked at least one pack/day. For example, during the second trimester, the odds ratio for smoking <5 cigarettes/day was 1.0 (95% confidence interval [CI] 0.6, 1.8), but the odds ratio (OR) for smoking 15 or more cigarettes/day was 1.6 (95% CI 0.9, 2.8), after adjustment for maternal age, education, race-ethnicity, sub-fertility, parity, folic acid supplement intake, body mass index, and study center. Among women who did not smoke, adjusted odds ratios suggested that secondhand smoke exposure at home, but not at work/school, was associated with modestly increased risk; the OR for home exposure was 1.3 (95% CI 0.9, 1.9). Results followed a similar pattern for some, but not all, specific suture types, but numbers for some groupings were small. CONCLUSIONS: The results suggest moderately increased risk of craniosynostosis among mothers who were the heaviest smokers and who continued to smoke after the first trimester. Results are somewhat equivocal, given that most confidence intervals included one.
Details
- Title: Subtitle
- Craniosynostosis and maternal smoking
- Creators
- Suzan L Carmichael - March of Dimes Foundation, California Research Division, Oakland, CaliforniaChen Ma - March of Dimes Foundation, California Research Division, Oakland, CaliforniaSonja A Rasmussen - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GeorgiaMargaret A Honein - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GeorgiaEdward J Lammer - Children's Hospital Research Institute, Oakland, CaliforniaGary M Shaw - March of Dimes Foundation, California Research Division, Oakland, CaliforniaNational Birth Defects Prevention Study
- Contributors
- Paul A Romitti (Contributor) - University of Iowa, Epidemiology
- Resource Type
- Journal article
- Publication Details
- Birth Defects Research Part A: Clinical and Molecular Teratology, Vol.66(2), pp.78-85
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company
- DOI
- 10.1002/bdra.20426
- PMID
- 18050313
- ISSN
- 1542-0752
- eISSN
- 1096-9926
- Number of pages
- 8
- Language
- English
- Date published
- 02/2008
- Academic Unit
- Epidemiology; Biostatistics
- Record Identifier
- 9984213370502771
Metrics
6 Record Views