Craniosynostosis and nutrient intake during pregnancy

Suzan L Carmichael; Sonja A Rasmussen; Edward J Lammer; Chen Ma; Gary M Shaw; National Birth Defects Prevention Study

doi:10.1002/bdra.20717

Journal article

Craniosynostosis and nutrient intake during pregnancy

Suzan L Carmichael, Sonja A Rasmussen, Edward J Lammer, Chen Ma, Gary M Shaw and National Birth Defects Prevention Study

Birth Defects Research Part A: Clinical and Molecular Teratology, Vol.88(12), pp.1032-1039

12/2010

DOI: 10.1002/bdra.20717

PMCID: PMC3136510

PMID: 20842649

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https://www.ncbi.nlm.nih.gov/pmc/articles/3136510View

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Abstract

OBJECTIVE: To examine the association of craniosynostosis with maternal intake of folic acid–containing supplements and dietary nutrients. METHODS: The study included deliveries from 1997 to 2005 from the National Birth Defects Prevention Study. Nonsyndromic infants with craniosynostosis (n = 815) were compared to nonmalformed, population-based liveborn control infants (n = 6789), by estimating adjusted odds ratios (AORs) and 95% confidence intervals (CIs) from logistic regression models that included mother's age, parity, race-ethnicity, education, body mass index, smoking, alcohol, fertility treatments, plurality, and study center. We compared quartiles of intake and specified nutrients as continuous. RESULTS: Intake of folic acid–containing supplements was not associated with craniosynostosis (AORs were close to 1). Analyses of dietary nutrients were restricted to mothers who took supplements during the first trimester (i.e., most women). Based on continuous specifications of nutrients, sagittal synostosis risk was significantly lower among women with higher intake of riboflavin and vitamins B6, E, and C; metopic synostosis risk was significantly higher among women with higher intakes of choline and vitamin B12; and coronal synostosis risk was significantly lower among women with higher intake of methionine and vitamin C. As examples, AORs for sagittal synostosis among women with intakes of vitamin B6 and riboflavin in the highest versus lowest quartiles were 0.4 (95% CI, 0.2–0.6) and 0.5 (95% CI, 0.3–0.7), respectively. CONCLUSION: This analysis suggests that dietary intake of certain nutrients may be associated with craniosynostosis, and results may vary by suture type.

craniosynostosis

diet

folic acid

nutrition

Details

Title: Subtitle: Craniosynostosis and nutrient intake during pregnancy
Creators: Suzan L Carmichael - California Research Division, March of Dimes Foundation, Oakland, California
Sonja A Rasmussen - Centers for Disease Control and Prevention, Atlanta, Georgia
Edward J Lammer - Children's Hospital Oakland Research Institute, Oakland, California
Chen Ma - California Research Division, March of Dimes Foundation, Oakland, California
Gary M Shaw - Stanford University School of Medicine, Palo Alto, California
National Birth Defects Prevention Study
Contributors: Paul A Romitti (Contributor) - University of Iowa, Epidemiology
Resource Type: Journal article
Publication Details: Birth Defects Research Part A: Clinical and Molecular Teratology, Vol.88(12), pp.1032-1039
DOI: 10.1002/bdra.20717
PMID: 20842649
PMCID: PMC3136510
NLM abbreviation: Birth Defects Res A Clin Mol Teratol
ISSN: 1542-0752
eISSN: 1096-9926
Publisher: Wiley Subscription Services, Inc., A Wiley Company
Number of pages: 8
Language: English
Date published: 12/2010
Academic Unit: Epidemiology; Biostatistics
Record Identifier: 9984214958502771

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