Journal article
Creation of a transgenic mouse for hair-cell gene targeting by using a modified bacterial artificial chromosome containing Prestin
Developmental dynamics, Vol.231(1), pp.199-203
09/2004
DOI: 10.1002/dvdy.20106
PMID: 15305300
Abstract
We made a transgenic mouse that expresses Cre recombinase activity in inner ear hair cells by using a modified bacterial artificial chromosome containing Prestin. Cre recombinase activity was restricted to inner and outer hair cells, a subset of vestibular hair cells, spiral and vestibular ganglia in the inner ear, and a subset of cells in the testis, epididymis, and ear bone. This mouse will be useful for hair-cell-specific gene targeting.
Details
- Title: Subtitle
- Creation of a transgenic mouse for hair-cell gene targeting by using a modified bacterial artificial chromosome containing Prestin
- Creators
- Yong Tian - Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TennesseeMingyuan LiBernd FritzschJian Zuo
- Resource Type
- Journal article
- Publication Details
- Developmental dynamics, Vol.231(1), pp.199-203
- DOI
- 10.1002/dvdy.20106
- PMID
- 15305300
- NLM abbreviation
- Dev Dyn
- ISSN
- 1058-8388
- eISSN
- 1097-0177
- Publisher
- United States
- Grant note
- MH61971 / NIMH NIH HHS DC04761 / NIDCD NIH HHS DC05168 / NIDCD NIH HHS DC00215 / NIDCD NIH HHS DC06471 / NIDCD NIH HHS EY12950 / NEI NIH HHS CA21765 / NCI NIH HHS
- Language
- English
- Date published
- 09/2004
- Academic Unit
- Iowa Neuroscience Institute; Biology; Craniofacial Anomalies Research Center
- Record Identifier
- 9984070874302771
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