Journal article
Creation of an open-access, mutation-defined fibroblast resource for neurological disease research
PloS one, Vol.7(8), pp.e43099-e43099
2012
DOI: 10.1371/journal.pone.0043099
PMCID: PMC3428297
PMID: 22952635
Abstract
Our understanding of the molecular mechanisms of many neurological disorders has been greatly enhanced by the discovery of mutations in genes linked to familial forms of these diseases. These have facilitated the generation of cell and animal models that can be used to understand the underlying molecular pathology. Recently, there has been a surge of interest in the use of patient-derived cells, due to the development of induced pluripotent stem cells and their subsequent differentiation into neurons and glia. Access to patient cell lines carrying the relevant mutations is a limiting factor for many centres wishing to pursue this research. We have therefore generated an open-access collection of fibroblast lines from patients carrying mutations linked to neurological disease. These cell lines have been deposited in the National Institute for Neurological Disorders and Stroke (NINDS) Repository at the Coriell Institute for Medical Research and can be requested by any research group for use in in vitro disease modelling. There are currently 71 mutation-defined cell lines available for request from a wide range of neurological disorders and this collection will be continually expanded. This represents a significant resource that will advance the use of patient cells as disease models by the scientific community.
Details
- Title: Subtitle
- Creation of an open-access, mutation-defined fibroblast resource for neurological disease research
- Creators
- Selina Wray - Department of Molecular Neuroscience, University College London Institute of Neurology, London, United KingdomMatthew SelfPatrick A LewisJan-Willem TaanmanNatalie S RyanColin J MahoneyYuying LiangMichael J DevineUna-Marie SheerinHenry HouldenHuw R MorrisDaniel HealyJose-Felix Marti-MassoElisavet PrezaSuzanne BarkerMargaret SutherlandRoderick A CorriveauMichael D'AndreaAnthony H V SchapiraRyan J UittiMark GuttmanGrzegorz OpalaBarbara Jasinska-MygaAndreas PuschmannChrister NilssonAlberto J EspayJaroslaw SlawekLudwig GutmannBradley F BoeveKevin BoylanA Jon StoesslOwen A RossNicholas J MaragakisJay Van GerpenMelissa GerstenhaberKatrina GwinnTed M DawsonOle IsacsonKaren S MarderLorraine N ClarkSerge E PrzedborskiSteven FinkbeinerJeffrey D RothsteinZbigniew K WszolekMartin N RossorJohn Hardy
- Resource Type
- Journal article
- Publication Details
- PloS one, Vol.7(8), pp.e43099-e43099
- DOI
- 10.1371/journal.pone.0043099
- PMID
- 22952635
- PMCID
- PMC3428297
- NLM abbreviation
- PLoS One
- ISSN
- 1932-6203
- eISSN
- 1932-6203
- Publisher
- Public Library of Science; United States
- Grant note
- G-0907 / Parkinson's UK R01 NS036630 / NINDS NIH HHS MR/J009482/1 / Medical Research Council Wellcome Trust RC2 NS069395 / NINDS NIH HHS NS036630 / NINDS NIH HHS G1001253 / Medical Research Council G0802760 / Medical Research Council P50NS072187 / NINDS NIH HHS RC2 NS070276 / NINDS NIH HHS F-1002 / Parkinson's UK P50 NS038370 / NINDS NIH HHS RC2 NS069422 / NINDS NIH HHS RC2NS069395 / NINDS NIH HHS P50 NS072187 / NINDS NIH HHS G0800437 / Medical Research Council 130 / Alzheimer's Society NS060113 / NINDS NIH HHS R01 NS039074 / NINDS NIH HHS G108/638 / Medical Research Council G1100479 / Medical Research Council G0701075 / Medical Research Council R56 NS036630 / NINDS NIH HHS G0700943 / Medical Research Council R21 NS050487 / NINDS NIH HHS R01 NS060113 / NINDS NIH HHS NS050487 / NINDS NIH HHS P50 NS038377 / NINDS NIH HHS RC2NS069422 / NINDS NIH HHS MC_G1000735 / Medical Research Council P50 NS072187-01S2 / NINDS NIH HHS 089698 / Wellcome Trust G-1104 / Parkinson's UK G0900421 / Medical Research Council NS38377 / NINDS NIH HHS P50NS38370 / NINDS NIH HHS
- Language
- English
- Date published
- 2012
- Academic Unit
- Neurology
- Record Identifier
- 9984020627402771
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