Journal article
Critical Closing Pressure by Diffuse Correlation Spectroscopy in a Neonatal Piglet Model
Acta neurochirurgica. Supplement, Vol.131, pp.295-299
2021
DOI: 10.1007/978-3-030-59436-7_55
PMID: 33839861
Abstract
The critical closing pressure (CrCP) of the cerebral vasculature is the arterial blood pressure (ABP) at which cerebral blood flow (CBF) ceases. Because the ABP of preterm infants is low and close to the CrCP, there is often no CBF during diastole. Thus, estimation of CrCP may become clinically relevant in preterm neonates. Transcranial Doppler (TCD) ultrasound has been used to estimate CrCP in preterm infants. Diffuse correlation spectroscopy (DCS) is a continuous, noninvasive optical technique that measures microvascular CBF. Our objective was to compare and validate CrCP measured by DCS versus TCD ultrasound. Hemorrhagic shock was induced in 13 neonatal piglets, and CBF was measured continuously by both modalities. CrCP was calculated using a model of cerebrovascular impedance, and CrCP determined by the two modalities showed good correlation by linear regression, median r
= 0.8 (interquartile range (IQR) 0.71-0.87), and Bland-Altman analysis showed a median bias of -3.5 (IQR -4.6 to -0.28). This is the first comparison of CrCP determined by DCS versus TCD ultrasound in a neonatal piglet model of hemorrhagic shock. The difference in CrCP between the two modalities may be due to differences in vasomotor tone within the microvasculature of the cerebral arterioles versus the macrovasculature of a major cerebral artery.
Details
- Title: Subtitle
- Critical Closing Pressure by Diffuse Correlation Spectroscopy in a Neonatal Piglet Model
- Creators
- Leah I Elizondo - Texas Children's HospitalEric L Vu - Northwestern UniversityKathleen K Kibler - Texas Children's HospitalDanielle R Rios - University of IowaR Blaine Easley - Texas Children's HospitalDean Andropoulos - Texas Children's HospitalSebastian Acosta - Texas Children's HospitalCraig Rusin - Texas Children's HospitalKenneth Brady - Northwestern UniversityChristopher J Rhee - Texas Children's Hospital
- Resource Type
- Journal article
- Publication Details
- Acta neurochirurgica. Supplement, Vol.131, pp.295-299
- DOI
- 10.1007/978-3-030-59436-7_55
- PMID
- 33839861
- eISBN
- 303059436X; 9783030594367
- ISSN
- 0065-1419
- eISSN
- 2197-8395
- Language
- English
- Date published
- 2021
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984354157402771
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