Critical Evaluation of Indices of Myocardial Contractility Derived from the Isovolumic Phase of Contraction

Charles W. Urschel; Pantel S. Vokonas; Andrew H. Henderson; James Liedtke; Lawrence D. Horwitz; Edmund H. Sonnenblick

doi:10.1159/000170791

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Critical Evaluation of Indices of Myocardial Contractility Derived from the Isovolumic Phase of Contraction

Journal article

Peer reviewed

Critical Evaluation of Indices of Myocardial Contractility Derived from the Isovolumic Phase of Contraction

Charles W. Urschel, Pantel S. Vokonas, Andrew H. Henderson, James Liedtke, Lawrence D. Horwitz and Edmund H. Sonnenblick

Cardiology, Vol.65(1), pp.4-22

1980

DOI: 10.1159/000170791

PMID: 7363278

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Abstract

The accuracy, sensitivity and reproducibility of several isovolumic force-velocity indices of myocardial contractility were compared. Contractile element velocity was calculated using both two-element (total pressure) and three-element (developed pressure) models of cardiac muscle. While all indices demonstrated comparable sensitivity to inotropic state, only Vmax using developed pressure was independent of preload and appeared to be a useful index of the myocardial contractile state.

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Details

Title: Subtitle: Critical Evaluation of Indices of Myocardial Contractility Derived from the Isovolumic Phase of Contraction
Creators: Charles W. Urschel - Harvard University
Pantel S. Vokonas - Harvard University
Andrew H. Henderson
James Liedtke - Harvard University
Lawrence D. Horwitz - Harvard University
Edmund H. Sonnenblick - Harvard University
Resource Type: Journal article
Publication Details: Cardiology, Vol.65(1), pp.4-22
DOI: 10.1159/000170791
PMID: 7363278
ISSN: 0008-6312
eISSN: 1421-9751
Number of pages: 19
Language: English
Date published: 1980
Academic Unit: Cardiovascular Medicine; Internal Medicine
Record Identifier: 9984656601002771

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