Journal article
Cross-Talk Between Insulin Signaling and G Protein-Coupled Receptors
Journal of cardiovascular pharmacology, Vol.70(2), pp.74-86
08/01/2017
DOI: 10.1097/FJC.0000000000000481
PMCID: PMC5734060
PMID: 28328746
Abstract
Diabetes is a major risk factor for the development of heart failure. One of the hallmarks of diabetes is insulin resistance associated with hyperinsulinemia. The literature shows that insulin and adrenergic signaling is intimately linked to each other; however, whether and how insulin may modulate cardiac adrenergic signaling and cardiac function remains unknown. Notably, recent studies have revealed that insulin receptor and beta(2) adrenergic receptor (beta(2)AR) forms a membrane complex in animal hearts, bringing together the direct contact between 2 receptor signaling systems, and forming an integrated and dynamic network. Moreover, insulin can drive cardiac adrenergic desensitization via protein kinase A and G protein-receptor kinases phosphorylation of the beta 2AR, which compromises adrenergic regulation of cardiac contractile function. In this review, we will explore the current state of knowledge linking insulin and G protein-coupled receptor signaling, especially beta-adrenergic receptor signaling in the heart, with emphasis on molecular insights regarding its role in diabetic cardiomyopathy.
Details
- Title: Subtitle
- Cross-Talk Between Insulin Signaling and G Protein-Coupled Receptors
- Creators
- Qin Fu - Huazhong University of Science and TechnologyQian Shi - †The Key Laboratory for Drug Target Research and Pharmacodynamic Evaluation of Hubei Province, Wuhan, ChinaToni M. West - University of California, DavisYang K. Xiang - VA Northern California Health Care System
- Resource Type
- Journal article
- Publication Details
- Journal of cardiovascular pharmacology, Vol.70(2), pp.74-86
- DOI
- 10.1097/FJC.0000000000000481
- PMID
- 28328746
- PMCID
- PMC5734060
- NLM abbreviation
- J Cardiovasc Pharmacol
- ISSN
- 0160-2446
- eISSN
- 1533-4023
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 13
- Grant note
- predoctoral fellowship of the American Heart Association; American Heart Association S10OD010389 / OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA HL127764; HL112413; S10 OD10389 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA 81473212; 81428022 / China NSFC; National Natural Science Foundation of China (NSFC) R01HL112413 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Language
- English
- Date published
- 08/01/2017
- Academic Unit
- Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984359769402771
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