Journal article
Cross-bridged Macrocyclic Chelators for Stable Complexation of Copper Radionuclides for PET Imaging
The quarterly journal of nuclear medicine and molecular imaging, Vol.52(2), pp.185-192
11/28/2007
PMCID: PMC4286870
PMID: 18043536
Abstract
Copper-64 (t
1/2
= 12.7 h, β
+
: 17.4%, E
β+max
= 656 keV; β
−
: 39%, E
β-max
= 573 keV) has emerged as an important non-standard positron-emitting radionuclide for PET imaging of diseased tissues. A significant challenge of working with copper radionuclides is that they must be delivered to the living system as a stable complex that is attached to a biological targeting molecule for effective imaging and therapy. Significant research has been devoted to the development of ligands that can stably chelate
64
Cu, in particular, the cross-bridged macrocyclic chelators. This review describes the coordination chemistry and biological behavior of
64
Cu-labeled cross-bridged complexes.
Details
- Title: Subtitle
- Cross-bridged Macrocyclic Chelators for Stable Complexation of Copper Radionuclides for PET Imaging
- Creators
- Carolyn J. Anderson - Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110. Department of Chemistry, University of New Hampshire, Durham, NH 03824Thaddeus J. Wadas - University of New HampshireEdward H. Wong - Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110. Department of Chemistry, University of New Hampshire, Durham, NH 03824Gary R. Weisman - Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110. Department of Chemistry, University of New Hampshire, Durham, NH 03824
- Resource Type
- Journal article
- Publication Details
- The quarterly journal of nuclear medicine and molecular imaging, Vol.52(2), pp.185-192
- PMID
- 18043536
- PMCID
- PMC4286870
- ISSN
- 1824-4785
- eISSN
- 1827-1936
- Language
- English
- Date published
- 11/28/2007
- Academic Unit
- Radiology; Radiation Oncology
- Record Identifier
- 9984312975102771
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