Cross-sectional and longitudinal reliability of semiquantitative osteoarthritis assessment at 1.0T extremity MRI: Multi-reader data from the MOST study

Michel Crema; Frank Roemer; Michael Nevitt; David Felson; Monica Marra; John Lynch; Irina Tolstykh; Cora Lewis; James Torner; Ali Guermazi

doi:10.1016/j.ocarto.2021.100214

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Cross-sectional and longitudinal reliability of semiquantitative osteoarthritis assessment at 1.0T extremity MRI: Multi-reader data from the MOST study

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Cross-sectional and longitudinal reliability of semiquantitative osteoarthritis assessment at 1.0T extremity MRI: Multi-reader data from the MOST study

Michel Crema, Frank Roemer, Michael Nevitt, David Felson, Monica Marra, John Lynch, Irina Tolstykh, Cora Lewis, James Torner and Ali Guermazi

Osteoarthritis and cartilage open, Vol.3(4), 100214

12/01/2021

DOI: 10.1016/j.ocarto.2021.100214

PMCID: PMC9718190

PMID: 36474762

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Abstract

OBJECTIVE: To determine reliability among four experienced and calibrated readers in cross-sectional and longitudinal semi-quantitative MRI assessments of knee osteoarthritis (OA) in the Multicenter Osteoarthritis (MOST) study. DESIGN: From all MOST participants with at least one knee with readable 60-month and 84-month paired knee MRIs (1.0 T extremity systems), we selected 10 subjects having a spectrum of baseline disease severity of cartilage, bone marrow lesions, and meniscal damage and a spectrum of longitudinal changes in severity at 24 months follow-up. MRIs were independently assessed using the WORMS grading system by four musculoskeletal radiologists with the chronological sequence known to the readers. Kappa statistics were used to determine agreement between each pair of readers and Kendalls coefficient of concordance to determine average agreement across readers. RESULTS: For most features, cross-sectional reliability was substantial to almost perfect. Regarding longitudinal reliability (detection of longitudinal change), inter-reader reliability as weighted kappa values ranged from 0.62 to 0.78 for cartilage damage, 0.75-0.88 for bone marrow lesions, 0.75-0.92 for meniscal tears, 0.67-0.95 for meniscal extrusion, 0.51-0.77 for bone attrition, 0.43-0.76 for osteophytes, 0.31-0.70 for Hoffa-synovitis, and 0.47-0.85 for effusion-synovitis. Kendalls coefficient ranged from 0.65 to 0.98. CONCLUSION: High levels of cross-sectional reliability and moderate to high longitudinal reliability was achieved using four experienced readers in semiquantitative MRI-assessment of most knee OA features.

Magnetic Resonance Imaging

Osteoarthritis

Cross-sectional study

Longitudinal study

Reliability

Details

Title: Subtitle: Cross-sectional and longitudinal reliability of semiquantitative osteoarthritis assessment at 1.0T extremity MRI: Multi-reader data from the MOST study
Creators: Michel Crema
Frank Roemer
Michael Nevitt
David Felson
Monica Marra
John Lynch
Irina Tolstykh
Cora Lewis
James Torner
Ali Guermazi
Resource Type: Journal article
Publication Details: Osteoarthritis and cartilage open, Vol.3(4), 100214
DOI: 10.1016/j.ocarto.2021.100214
PMID: 36474762
PMCID: PMC9718190
NLM abbreviation: Osteoarthr Cartil Open
ISSN: 2665-9131
Publisher: Elsevier
Grant note: DOI: 10.13039/100000002, name: National Institutes of Health; DOI: 10.13039/100000049, name: National Institute on Aging, award: AR47785, U01-AG-18820, U01-AG-18832, U01-AG-18947, U01-AG-19069
Language: English
Date published: 12/01/2021
Academic Unit: Neurology; Epidemiology; Injury Prevention Research Center; Neurosurgery
Record Identifier: 9984438859302771

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