Cross talk between the cytoplasm and nucleus during development and disease

Lori L Wallrath; Jens Bohnekamp; Thomas M Magin

doi:10.1016/j.gde.2016.03.007

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Cross talk between the cytoplasm and nucleus during development and disease

Journal article

Peer reviewed

Cross talk between the cytoplasm and nucleus during development and disease

Lori L Wallrath, Jens Bohnekamp and Thomas M Magin

Current opinion in genetics & development, Vol.37, pp.129-136

04/2016

DOI: 10.1016/j.gde.2016.03.007

PMID: 27110666

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Abstract

Mechanotransduction is a process whereby mechanical stimuli outside the cell are sensed by components of the plasma membrane and transmitted as signals through the cytoplasm that terminate in the nucleus. The nucleus responds to these signals by altering gene expression. During mechanotransduction, complex networks of proteins are responsible for cross talk between the cytoplasm and the nucleus. These proteins include cell membrane receptors, cytoplasmic filaments, LINC complex members that bridge the nucleus and cytoplasm, and nuclear envelope proteins that connect to the chromatin. Mechanotransduction also plays a critical role in development. Furthermore, it is possible that disrupted mechanotransduction leads to changes in gene expression that underlie the pathogenic mechanisms of disease.

Animals

Nuclear Envelope - genetics

Cell Nucleus - genetics

Humans

Cell Membrane - genetics

Cytoplasm - genetics

RNA, Long Noncoding - genetics

Chromatin - genetics

Mechanotransduction, Cellular - genetics

Details

Title: Subtitle: Cross talk between the cytoplasm and nucleus during development and disease
Creators: Lori L Wallrath - Department of Biochemistry, University of Iowa, Iowa City, IA 52242, USA. Electronic address: lori-wallrath@uiowa.edu
Jens Bohnekamp - Institute of Biology and Translational Center for Regenerative Medicine, University of Leipzig, D-04103 Leipzig, Germany
Thomas M Magin - Institute of Biology and Translational Center for Regenerative Medicine, University of Leipzig, D-04103 Leipzig, Germany
Resource Type: Journal article
Publication Details: Current opinion in genetics & development, Vol.37, pp.129-136
DOI: 10.1016/j.gde.2016.03.007
PMID: 27110666
NLM abbreviation: Curr Opin Genet Dev
ISSN: 0959-437X
eISSN: 1879-0380
Publisher: England
Grant note: R21 AR064894 / NIAMS NIH HHS
Language: English
Date published: 04/2016
Academic Unit: Biochemistry and Molecular Biology; University College Courses
Record Identifier: 9984025259702771

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