Crossover trial of gabapentin and memantine as treatment for acquired nystagmus

Matthew J Thurtell; Anand C Joshi; Alice C Leone; Robert L Tomsak; Gregory S Kosmorsky; John S Stahl; R John Leigh

doi:10.1002/ana.21991

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Crossover trial of gabapentin and memantine as treatment for acquired nystagmus

Journal article

Open access

Peer reviewed

Crossover trial of gabapentin and memantine as treatment for acquired nystagmus

Matthew J Thurtell, Anand C Joshi, Alice C Leone, Robert L Tomsak, Gregory S Kosmorsky, John S Stahl and R John Leigh

Annals of neurology, Vol.67(5), pp.676-680

05/2010

DOI: 10.1002/ana.21991

PMCID: PMC3064518

PMID: 20437565

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https://www.ncbi.nlm.nih.gov/pmc/articles/3064518View

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Abstract

We conducted a masked, crossover, therapeutic trial of gabapentin (1,200mg/day) versus memantine (40 mg/day) for acquired nystagmus in 10 patients (aged 28-61 years; 7 female; 3 multiple sclerosis [MS]; 6 post-stroke; 1 post-traumatic). Nystagmus was pendular in 6 patients (4 oculopalatal tremor; 2 MS) and jerk upbeat, hemi-seesaw, torsional, or upbeat-diagonal in each of the others. For the group, both drugs reduced median eye speed (p < 0.001), gabapentin by 32.8% and memantine by 27.8%, and improved visual acuity (p < 0.05). Each patient improved with 1 or both drugs. Side effects included unsteadiness with gabapentin and lethargy with memantine. Both drugs should be considered as treatment for acquired forms of nystagmus.

Cyclohexanecarboxylic Acids - therapeutic use

Excitatory Amino Acid Antagonists - therapeutic use

Humans

Middle Aged

Male

Eye Movements - drug effects

Cross-Over Studies

Amines - therapeutic use

Adult

Female

gamma-Aminobutyric Acid - therapeutic use

Memantine - therapeutic use

Nystagmus, Pathologic - drug therapy

Details

Title: Subtitle: Crossover trial of gabapentin and memantine as treatment for acquired nystagmus
Creators: Matthew J Thurtell - Neurology Service, Veterans Affairs Medical Center, Cleveland OH, USA
Anand C Joshi
Alice C Leone
Robert L Tomsak
Gregory S Kosmorsky
John S Stahl
R John Leigh
Resource Type: Journal article
Publication Details: Annals of neurology, Vol.67(5), pp.676-680
DOI: 10.1002/ana.21991
PMID: 20437565
PMCID: PMC3064518
NLM abbreviation: Ann Neurol
ISSN: 0364-5134
eISSN: 1531-8249
Publisher: United States
Grant note: R01 EY006717-25 / NEI NIH HHS R01 EY006717 / NEI NIH HHS EY06717 / NEI NIH HHS
Language: English
Date published: 05/2010
Academic Unit: Neurology; Ophthalmology and Visual Sciences
Record Identifier: 9983980081002771

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