Journal article
Cryoglobulinemia and Glomerular Rhomboid Inclusions in a Child With Acute Kidney Injury
American journal of kidney diseases, Vol.53(5), pp.866-870
2009
DOI: 10.1053/j.ajkd.2009.01.015
PMCID: PMC3050500
PMID: 19303686
Abstract
Cryoglobulinemia is rarely reported in children, and kidney failure secondary to cryoglobulinemia is even more uncommon. We report the case of a 7-year-old boy with cryoglobulins and a systemic illness, including persistent fever, arthralgias, rash, hypocomplementemia, and acute kidney injury associated with nephritic urine sediment. An extensive workup showed no infectious, neoplastic, or rheumatological cause of his kidney injury. The kidney biopsy specimen showed membranoproliferative glomerulonephritis type 1 with electron microscopic evidence of rhomboid crystalloid inclusions. These inclusions have rarely been reported in adult patients with cryoglobulinemia. The patient underwent spontaneous remission, including full recovery of kidney function, and required no immune suppression. The patient's course is consistent with cryoglobulinemia-associated kidney injury, which supports the inclusion of essential cryoglobulinemia in the differential diagnosis of pediatric patients with hypocomplementemic glomerulonephritis.
Details
- Title: Subtitle
- Cryoglobulinemia and Glomerular Rhomboid Inclusions in a Child With Acute Kidney Injury
- Creators
- Carla M Nester - Department of Internal Medicine, Division of Nephrology, University of Iowa Carver College of Medicine and Children's Hospital, Iowa City, IAEric J Benner - Department of Pediatrics, Nephropathology Unit, University of North Carolina, Chapel Hill, NCMathieu Latour - Department of Pathology and Laboratory Medicine, Nephropathology Unit, University of North Carolina, Chapel Hill, NCVolker Nickeleit - Department of Pathology and Laboratory Medicine, Nephropathology Unit, University of North Carolina, Chapel Hill, NCHarvey Hamrick - Department of Pediatrics, Nephropathology Unit, University of North Carolina, Chapel Hill, NCWilliam Primack - University of North Carolina School of Medicine, UNC Kidney Center, Chapel Hill, NC
- Resource Type
- Journal article
- Publication Details
- American journal of kidney diseases, Vol.53(5), pp.866-870
- DOI
- 10.1053/j.ajkd.2009.01.015
- PMID
- 19303686
- PMCID
- PMC3050500
- NLM abbreviation
- Am J Kidney Dis
- ISSN
- 0272-6386
- eISSN
- 1523-6838
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2009
- Academic Unit
- Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Internal Medicine
- Record Identifier
- 9984093335002771
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