Journal article
Crypts are the site of intestinal fluid and electrolyte secretion
Science (American Association for the Advancement of Science), Vol.218(4578), pp.1219-1221
12/17/1982
DOI: 10.1126/science.6293054
PMID: 6293054
Abstract
The site of adenosine 3',5'-monophosphate-mediated fluid and electrolyte secretion across mammalian large intestine was found to be the crypts of Lieberkühn by means of two techniques. First, the formation of fluid droplets was visualized on the oil-covered mucosal surface directly over crypt duct openings when secretion was stimulated. Second, microelectrode impalement of individual surface and crypt cells revealed that only crypts cells produced a pattern of secretagogue induced alterations in membrane potential and resistance that was characteristic of secretory epithelia.
Details
- Title: Subtitle
- Crypts are the site of intestinal fluid and electrolyte secretion
- Creators
- M J WelshP L SmithM FrommR A Frizzell
- Resource Type
- Journal article
- Publication Details
- Science (American Association for the Advancement of Science), Vol.218(4578), pp.1219-1221
- Publisher
- United States
- DOI
- 10.1126/science.6293054
- PMID
- 6293054
- ISSN
- 0036-8075
- eISSN
- 1095-9203
- Grant note
- AM-27524 / NIADDK NIH HHS HL-07159 / NHLBI NIH HHS AM-31091 / NIADDK NIH HHS
- Language
- English
- Date published
- 12/17/1982
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Pulmonary, Critical Care, and Occupational Medicine; Fraternal Order of Eagles Diabetes Research Center; Neurosurgery; Internal Medicine
- Record Identifier
- 9984020704502771
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