Crystal Structure of Guanidinoacetate Methyltransferase from Rat Liver: A Model Structure of Protein Arginine Methyltransferase

Junichi Komoto; Yafei Huang; Yoshimi Takata; Taro Yamada; Kiyoshi Konishi; Hirofumi Ogawa; Tomoharu Gomi; Motoji Fujioka; Fusao Takusagawa

doi:10.1016/S0022-2836(02)00448-5

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Crystal Structure of Guanidinoacetate Methyltransferase from Rat Liver: A Model Structure of Protein Arginine Methyltransferase

Journal article

Peer reviewed

Crystal Structure of Guanidinoacetate Methyltransferase from Rat Liver: A Model Structure of Protein Arginine Methyltransferase

Junichi Komoto, Yafei Huang, Yoshimi Takata, Taro Yamada, Kiyoshi Konishi, Hirofumi Ogawa, Tomoharu Gomi, Motoji Fujioka and Fusao Takusagawa

Journal of molecular biology, Vol.320(2), pp.223-235

2002

DOI: 10.1016/S0022-2836(02)00448-5

PMID: 12079381

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Abstract

Guanidinoacetate methyltransferase (GAMT) is the enzyme that catalyzes the last step of creatine biosynthesis. The enzyme is found in abundance in the livers of all vertebrates. Recombinant rat liver GAMT has been crystallized with

methyltransferase

guanidinoacetate methyltransferase

creatine biosynthesis

protein arginine methyltransferase

enzyme catalytic mechanism

Details

Title: Subtitle: Crystal Structure of Guanidinoacetate Methyltransferase from Rat Liver: A Model Structure of Protein Arginine Methyltransferase
Creators: Junichi Komoto - Department of Molecular Biosciences, The University of Kansas, 1200 Sunnyside Avenue, 2034 Howorth Hall, Lawrence, KS 66045-7534, USA
Yafei Huang - Department of Molecular Biosciences, The University of Kansas, 1200 Sunnyside Avenue, 2034 Howorth Hall, Lawrence, KS 66045-7534, USA
Yoshimi Takata - Department of Molecular Biosciences, The University of Kansas, 1200 Sunnyside Avenue, 2034 Howorth Hall, Lawrence, KS 66045-7534, USA
Taro Yamada - Department of Molecular Biosciences, The University of Kansas, 1200 Sunnyside Avenue, 2034 Howorth Hall, Lawrence, KS 66045-7534, USA
Kiyoshi Konishi - Department of Biochemistry, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama 930-0194, Japan
Hirofumi Ogawa - Department of Biochemistry, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama 930-0194, Japan
Tomoharu Gomi - Department of Biochemistry, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama 930-0194, Japan
Motoji Fujioka - Department of Biochemistry, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama 930-0194, Japan
Fusao Takusagawa - Department of Molecular Biosciences, The University of Kansas, 1200 Sunnyside Avenue, 2034 Howorth Hall, Lawrence, KS 66045-7534, USA
Resource Type: Journal article
Publication Details: Journal of molecular biology, Vol.320(2), pp.223-235
Publisher: Elsevier Ltd
DOI: 10.1016/S0022-2836(02)00448-5
PMID: 12079381
ISSN: 0022-2836
eISSN: 1089-8638
Language: English
Date published: 2002
Academic Unit: Neurology
Record Identifier: 9984020848402771

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