Cumulative exposure to high estradiol levels during the follicular phase of IVF cycles negatively affects implantation.

Murat Arslan; Silvina Bocca; Ebru Ozturk Arslan; E. Hakan Duran; Laurel Stadtmauer; Sergio Oehninger

doi:10.1007/s10815-006-9101-x

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Cumulative exposure to high estradiol levels during the follicular phase of IVF cycles negatively affects implantation.

Journal article

Open access

Peer reviewed

Cumulative exposure to high estradiol levels during the follicular phase of IVF cycles negatively affects implantation.

Murat Arslan, Silvina Bocca, Ebru Ozturk Arslan, E. Hakan Duran, Laurel Stadtmauer and Sergio Oehninger

Journal of assisted reproduction and genetics, Vol.24(4), pp.111-117

04/01/2007

DOI: 10.1007/s10815-006-9101-x

PMCID: PMC3455065

PMID: 17450430

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Abstract

PURPOSE: To investigate the effect of the cumulative exposure to estradiol (E(2)) during the follicular phase on IVF outcome. METHODS: Patients were stimulated with recombinant FSH after GnRH agonist suppression and had a day 3-embryo transfer. Estrogen exposure was determined as the area under the curve (AUC) for serum E(2) levels measured from the first day of stimulation through the day after hCG administration. RESULTS: E(2) AUC thresholds for 10th and 90th percentiles were 4704 pg/ml and 16338 pg/ml, respectively. The pregnancy and implantation rates were highest in the 10th-90th percentile group, and were statistically higher in this group than in the >90th percentile group (54.6% vs. 33.3% and 24.8% and 12.9%, respectively, for pregnancy and implantation rates, P < 0.05). Recovered mature oocytes, fertilization, and number and mean score of transferred embryos were similar. CONCLUSIONS: High cumulative E(2) exposure during the follicular phase of IVF cycles has detrimental effects on implantation.

Pregnancy

Obstetrics and Gynecology

Adult

Chorionic Gonadotropin

Embryo Implantation

Embryo Transfer

Estradiol

Female

Fertilization in Vitro

Follicular Phase

Humans

Ovulation Induction

Retrospective Studies

Details

Title: Subtitle: Cumulative exposure to high estradiol levels during the follicular phase of IVF cycles negatively affects implantation.
Creators: Murat Arslan
Silvina Bocca
Ebru Ozturk Arslan
E. Hakan Duran - University of Iowa
Laurel Stadtmauer
Sergio Oehninger
Resource Type: Journal article
Publication Details: Journal of assisted reproduction and genetics, Vol.24(4), pp.111-117
DOI: 10.1007/s10815-006-9101-x
PMID: 17450430
PMCID: PMC3455065
NLM abbreviation: J Assist Reprod Genet
ISSN: 1058-0468
Language: English
Date published: 04/01/2007
Academic Unit: Obstetrics and Gynecology
Record Identifier: 9983557121402771

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