Journal article
Curative treatment for stage IIIC2 cervical cancer: what to expect?
Reports of practical oncology and radiotherapy, Vol.28(3), pp.332-339
01/01/2023
DOI: 10.5603/RPOR.a2023.0036
PMCID: PMC10547400
PMID: 37795398
Abstract
Background: Since the GOG125 study, treating radically patients with positive para-aortic lymph nodes has been a valid approach. Nevertheless, literature lacks data on how to better treat these patients since they are usually excluded from trials. In this study, we aimed to report the outcomes of patients with advanced cervical cancer and positive para-aortic lymph nodes (PAN) treated in a single tertiary/academic institution and try to identify variables that may impact survival.
Materials and methods: We retrospectively reviewed patients with positive para-aortic lymph nodes treated in our institution. Demographic variables and treatment options were assessed and their impact on overall survival (OS), locorregional control, distant metastasis free survival, and para-aortic lymph node progression was analyzed.
Results: We assessed 65 patients treated from April 2010 to May 2017. Median OS was 38.7 months. Median locorregional and para-aortic progression free survivals were not reached. Median distant metastasis progression-free survival was 64.3 months. Better ECOG performance status (p > 0.001), concurrent chemotherapy (p = 0.031), and brachytherapy (p = 0.02) were independently related to better overall survival.
Conclusion: Patients with current stage IIIC2 cervix cancer may present long term survival. Treating positive PAN cervical cancer patients with concurrent chemoradiation including brachytherapy with curative intent should be standard. Poor PS and more advanced pelvic disease may represent a higher risk for worse outcomes. Distant metastases are still a challenge for disease control.
Details
- Title: Subtitle
- Curative treatment for stage IIIC2 cervical cancer: what to expect?
- Creators
- Geovanne Pedro Mauro - Universidade de São PauloVinicius de Aquino Calheiros - Univ Sao Paulo, Fac Med FMUSP, Dept Radiol & Oncol, Sao Paulo, SP, BrazilMatheus Sorgi Vonsowski - Universidade de São PauloTalita Avelar - Universidade de São PauloHeloisa de Andrade Carvalho - Univ Sao Paulo, Fac Med FMUSP, Dept Radiol & Oncol, Sao Paulo, SP, Brazil
- Resource Type
- Journal article
- Publication Details
- Reports of practical oncology and radiotherapy, Vol.28(3), pp.332-339
- DOI
- 10.5603/RPOR.a2023.0036
- PMID
- 37795398
- PMCID
- PMC10547400
- NLM abbreviation
- Rep Pract Oncol Radiother
- ISSN
- 1507-1367
- eISSN
- 2083-4640
- Publisher
- Via Medica
- Number of pages
- 8
- Language
- English
- Date published
- 01/01/2023
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984914017802771
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