Journal article
Curcumin prevents chronic alcohol-induced liver disease involving decreasing ROS generation and enhancing antioxidative capacity
Phytomedicine (Stuttgart), Vol.19(6), pp.545-550
04/15/2012
DOI: 10.1016/j.phymed.2011.12.006
PMID: 22445643
Abstract
Our previous study found that curcumin, a major active component of turmeric, could ameliorate ethanol-induced hepatocytes oxidative stress in vitro. The objective of this work was to investigate the effect of curcumin on chronic alcoholic liver disease (ALD) in vivo. Ethanol-exposed (2.4g/kg/day ethanol for the initial 4 weeks and 4g/kg/day for another 2 weeks) Balb/c mice were simultaneously treated with curcumin for 6 weeks. The results showed that curcumin attenuated ethanol-induced histopathological changes of the liver and ameliorated the evident release of cellular alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Ethanol exposure resulted in reactive oxygen species (ROS) generation, malondialdehyde (MDA) elevation, glutathione (GSH) depletion and antioxidant defense system impairment, which were significantly reversed by curcumin treatment. In conclusion, curcumin provided protection against chronic ALD and the mechanism might be related to the alleviation of oxidative damage.
Details
- Title: Subtitle
- Curcumin prevents chronic alcohol-induced liver disease involving decreasing ROS generation and enhancing antioxidative capacity
- Creators
- Shuang Rong - Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, PR ChinaYanting Zhao - Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, PR ChinaWei Bao - Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, PR ChinaXiao Xiao - Huazhong University of Science and TechnologyDi Wang - Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, PR ChinaAndreas K Nussler - Department of Traumatology, Technical University of Munich, 22 Ismaningerstr., 81675 Munich, GermanyHong Yan - Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, PR ChinaPin Yao - Huazhong University of Science and TechnologyLiegang Liu - Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, PR China
- Resource Type
- Journal article
- Publication Details
- Phytomedicine (Stuttgart), Vol.19(6), pp.545-550
- DOI
- 10.1016/j.phymed.2011.12.006
- PMID
- 22445643
- NLM abbreviation
- Phytomedicine
- ISSN
- 0944-7113
- eISSN
- 1618-095X
- Publisher
- Elsevier GmbH
- Language
- English
- Date published
- 04/15/2012
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9983995046402771
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