Current Opinion on the Clinical Approach to the Diagnosis of Mitochondrial Disease

Peterus Thajeb; Dao-Fu Dai

doi:10.1016/S1873-9598(08)70020-6

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Current Opinion on the Clinical Approach to the Diagnosis of Mitochondrial Disease

Journal article

Open access

Peer reviewed

Current Opinion on the Clinical Approach to the Diagnosis of Mitochondrial Disease

Peterus Thajeb and Dao-Fu Dai

International journal of gerontology, Vol.1(1), pp.22-30

2007

DOI: 10.1016/S1873-9598(08)70020-6

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Abstract

Knowing the molecular basis of mitochondria, the aging process of the mitochondrial machinery and recognition of its disorders are becoming more important in modern medicine. The diagnosis of mitochondrial disease (MtD) is possible only when one is aware of it. The heterogeneity of MtD in terms of its phenotype expression and genotype variations makes MtD very unique. Current opinion on the clinical approach to patients with suspected mitochondrial disorders are highlighted in this review.

mutation

nuclear DNA

aging

mitochondrial DNA

mitochondrial disease

oxidative phosphorylation

Details

Title: Subtitle: Current Opinion on the Clinical Approach to the Diagnosis of Mitochondrial Disease
Creators: Peterus Thajeb - Department of Neurology, Mackay Memorial Hospital, Taipei, Taiwan
Dao-Fu Dai - Department of Pathology, University of Washington School of Medicine, Seattle, USA
Resource Type: Journal article
Publication Details: International journal of gerontology, Vol.1(1), pp.22-30
DOI: 10.1016/S1873-9598(08)70020-6
ISSN: 1873-9598
eISSN: 1873-958X
Publisher: Elsevier B.V
Language: English
Date published: 2007
Academic Unit: Pathology; Iowa Neuroscience Institute; Radiation Oncology
Record Identifier: 9984070149002771

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