Current Perspectives on Pathobiology of the Ductus Arteriosus

Jason Z Stoller; Sara B DeMauro; John M Dagle; Jeff Reese

doi:10.4172/2155-9880.S8-001

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Current Perspectives on Pathobiology of the Ductus Arteriosus

Journal article

Open access

Current Perspectives on Pathobiology of the Ductus Arteriosus

Jason Z Stoller, Sara B DeMauro, John M Dagle and Jeff Reese

Journal of clinical & experimental cardiology, Vol.8(1), S8-001

06/15/2012

DOI: 10.4172/2155-9880.S8-001

PMCID: PMC3601484

PMID: 23519783

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https://www.ncbi.nlm.nih.gov/pmc/articles/3601484View

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Abstract

The ductus arteriosus (DA) shunts blood away from the lungs during fetal life, but at birth this shunt is no longer needed and the vessel rapidly constricts. Postnatal persistence of the DA, patent ductus arteriosus (PDA), is predominantly a detrimental condition for preterm infants but is simultaneously a condition required to maintain systemic blood flow for infants born with certain severe congenital heart defects. Although PDA in preterm infants is associated with significant morbidities, there is controversy regarding whether PDA is truly causative. Despite advances in our understanding of the pathobiology of PDA, the optimal treatment strategy for PDA in preterm infants is unclear. Here we review recent studies that have continued to elucidate the fundamental mechanisms of DA development and pathogenesis.

Patent ductus arteriosus

Vascular development

Details

Title: Subtitle: Current Perspectives on Pathobiology of the Ductus Arteriosus
Creators: Jason Z Stoller - Department of Pediatrics, University of Pennsylvania School of Medicine, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Sara B DeMauro - Department of Pediatrics, University of Pennsylvania School of Medicine, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA
John M Dagle - Departments of Pediatrics and Biochemistry, University of Iowa, Iowa City, IA 52242, USA
Jeff Reese - Departments of Pediatrics, and Cell and Developmental Biology; Vanderbilt University, Nashville, TN, 37232, USA
Resource Type: Journal article
Publication Details: Journal of clinical & experimental cardiology, Vol.8(1), S8-001
DOI: 10.4172/2155-9880.S8-001
PMID: 23519783
PMCID: PMC3601484
NLM abbreviation: J Clin Exp Cardiolog
ISSN: 2155-9880
eISSN: 2155-9880
Grant note: K08 HL086633 || HL / National Heart, Lung, and Blood Institute : NHLBI
Language: English
Date published: 06/15/2012
Academic Unit: Stead Family Department of Pediatrics; Epidemiology; Biochemistry and Molecular Biology; Neonatology
Record Identifier: 9984025290302771

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