Journal article
Current Status of Gene Therapy for Inherited Lung Diseases
Annual review of physiology, Vol.65(1), pp.585-612
03/2003
DOI: 10.1146/annurev.physiol.65.092101.142426
PMCID: PMC1857313
PMID: 12524461
Abstract
Gene therapy as a treatment modality for pulmonary disorders has attracted significant interest over the past decade. Since the initiation of the first clinical trials for cystic fibrosis lung disease using recombinant adenovirus in the early 1990s, the field has encountered numerous obstacles including vector inflammation, inefficient delivery, and vector production. Despite these obstacles, enthusiasm for lung gene therapy remains high. In part, this enthusiasm is fueled through the diligence of numerous researchers whose studies continue to reveal great potential of new gene transfer vectors that demonstrate increased tropism for airway epithelia. Several newly identified serotypes of adeno-associated virus have demonstrated substantial promise in animal models and will likely surface soon in clinical trials. Furthermore, an increased understanding of vector biology has also led to the development of new technologies to enhance the efficiency and selectivity of gene delivery to the lung. Although the promise of gene therapy to the lung has yet to be realized, the recent concentrated efforts in the field that focus on the basic virology of vector development will undoubtedly reap great rewards over the next decade in treating lung diseases.
Details
- Title: Subtitle
- Current Status of Gene Therapy for Inherited Lung Diseases
- Creators
- Ryan A Driskell - Center for Gene Therapy of Cystic Fibrosis and Other Genetic Diseases, Department of Anatomy and Cell Biology, and the Department of Internal Medicine University of Iowa, Iowa City, Iowa 52242; e-mailJohn F Engelhardt - Center for Gene Therapy of Cystic Fibrosis and Other Genetic Diseases, Department of Anatomy and Cell Biology, and the Department of Internal Medicine University of Iowa, Iowa City, Iowa 52242; e-mail
- Resource Type
- Journal article
- Publication Details
- Annual review of physiology, Vol.65(1), pp.585-612
- DOI
- 10.1146/annurev.physiol.65.092101.142426
- PMID
- 12524461
- PMCID
- PMC1857313
- NLM abbreviation
- Annu Rev Physiol
- ISSN
- 0066-4278
- eISSN
- 1545-1585
- Language
- English
- Date published
- 03/2003
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Anatomy and Cell Biology; Radiation Oncology; Internal Medicine
- Record Identifier
- 9984025412202771
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