Current approaches to anticoagulation for reducing risk of atrial fibrillation-related stroke

Cynthia A Sanoski

doi:10.1177/0897190012452309

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Current approaches to anticoagulation for reducing risk of atrial fibrillation-related stroke

Journal article

Peer reviewed

Current approaches to anticoagulation for reducing risk of atrial fibrillation-related stroke

Cynthia A Sanoski

Journal of pharmacy practice, Vol.26(3), pp.204-213

06/2013

DOI: 10.1177/0897190012452309

PMID: 22842506

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Abstract

Stroke is a major cause of death and disability and, as such, is associated with a heavy socioeconomic burden. Atrial fibrillation (AF) is an independent risk factor for ischemic stroke, and AF-related stroke tends to be more severe and poses a higher risk of recurrence than non-AF-related stroke. Anticoagulant prophylaxis with warfarin is effective in preventing stroke in eligible patients with AF, but in real-world practice this agent, though inexpensive, is underutilized. Moreover, warfarin has notable drawbacks that result in suboptimal anticoagulation and, as a result, greater disease burden and higher costs. Newer oral antithrombotic drugs with a wide therapeutic window and no requirement for routine coagulation monitoring may be as efficacious as warfarin and, given the costs associated with managing warfarin therapy, they may also prove to be more cost effective.

Administration, Oral

Animals

Anticoagulants - administration & dosage

Anticoagulants - economics

Anticoagulants - therapeutic use

Atrial Fibrillation - complications

Atrial Fibrillation - drug therapy

Brain Ischemia - etiology

Brain Ischemia - prevention & control

Cost-Benefit Analysis

Drug Costs

Humans

Risk Factors

Secondary Prevention

Stroke - etiology

Stroke - prevention & control

Warfarin - administration & dosage

Warfarin - economics

Warfarin - therapeutic use

Details

Title: Subtitle: Current approaches to anticoagulation for reducing risk of atrial fibrillation-related stroke
Creators: Cynthia A Sanoski - Thomas Jefferson University
Resource Type: Journal article
Publication Details: Journal of pharmacy practice, Vol.26(3), pp.204-213
DOI: 10.1177/0897190012452309
PMID: 22842506
ISSN: 0897-1900
eISSN: 1531-1937
Language: English
Date published: 06/2013
Academic Unit: Pharmacy; Pharmacy Practice and Science
Record Identifier: 9984721228502771

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