Journal article
Current aspects of formulation efforts and pore lifetime related to microneedle treatment of skin
Expert opinion on drug delivery, Vol.7(5), pp.617-629
05/01/2010
DOI: 10.1517/17425241003663228
PMCID: PMC2858255
PMID: 20205604
Abstract
Importance of the field: The efficacy of microneedles in the area of transdermal drug delivery is well documented. Multiple studies have shown that enhancement of skin permeation by means of the creation of microscopic pores in the stratum corneum can greatly improve the delivery rates of drugs. However, skin pretreatment with microneedles is not the only factor affecting drug transport rates. Other factors, including drug formulation and rate of micropore closure, are also important for optimizing delivery by this route.
Areas covered in this review: This review aims to highlight work that has been done in these areas, with an emphasis on drug formulation parameters that affect transdermal flux.
What the reader will gain: This review creates an appreciation for the many factors affecting microneedle-enhanced delivery. Most results clearly indicate that microneedle skin pretreatment by itself may have different effects on drug transport depending on the formulation used, and formulation characteristics have different effects on the transport through untreated skin and microneedle-treated skin. Several formulation approaches are reported to optimize microneedle-enhanced drug delivery, including co-solvent use, vesicular, nanoparticulate and gel systems.
Take home message: In addition to well-established factors that affect microneedle-assisted delivery (geometry, type of microneedle, etc.), formulation and pore viability are also critical factors that must be considered.
Details
- Title: Subtitle
- Current aspects of formulation efforts and pore lifetime related to microneedle treatment of skin
- Creators
- Mikolaj Milewski - 1University of Kentucky, College of Pharmacy, Department of Pharmaceutical Sciences, 459 Wethington Bldg, 900 South Limestone Street, Lexington, KY 40536-0082, USANicole K Brogden - 1University of Kentucky, College of Pharmacy, Department of Pharmaceutical Sciences, 459 Wethington Bldg, 900 South Limestone Street, Lexington, KY 40536-0082, USAAudra L Stinchcomb - 2University of Kentucky, College of Pharmacy, Department of Pharmaceutical Sciences, 459 Wethington Bldg, 900 South Limestone Street, Lexington, KY 40536-0082, USA +1 859 323 6192; +1 859 257 2787; astin2@email.uky.edu
- Resource Type
- Journal article
- Publication Details
- Expert opinion on drug delivery, Vol.7(5), pp.617-629
- DOI
- 10.1517/17425241003663228
- PMID
- 20205604
- PMCID
- PMC2858255
- NLM abbreviation
- Expert Opin Drug Deliv
- ISSN
- 1742-5247
- eISSN
- 1744-7593
- Publisher
- Informa UK Ltd
- Language
- English
- Date published
- 05/01/2010
- Academic Unit
- Dermatology; Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984025457302771
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