Journal article
Current clinical practices and challenges in molecular testing: a GOAL Consortium Hematopathology Working Group report
Blood advances, Vol.7(16), pp.4599-4607
08/22/2023
DOI: 10.1182/bloodadvances.2023010149
PMCID: PMC10425685
PMID: 37236162
Abstract
•Survey results from 18 academic laboratories reveal differences in molecular testing approaches and practices for hematologic neoplasms.•Shared understanding of the capabilities and limitations of current and future molecular testing will help optimize patient care.
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While molecular testing of hematologic malignancies is now standard of care, there is variability in practice and testing capabilities between different academic laboratories, with common questions arising on how to best meet clinical expectations. A survey was sent to hematopathology subgroup members of the Genomics Organization for Academic Laboratories consortium to assess current and future practice and potentially establish a reference for peer institutions. Responses were received from 18 academic tertiary-care laboratories regarding next-generation sequencing (NGS) panel design, sequencing protocols and metrics, assay characteristics, laboratory operations, case reimbursement, and development plans. Differences in NGS panel size, use, and gene content were reported. Gene content for myeloid processes was reported to be generally excellent, while genes for lymphoid processes were less well covered. The turnaround time (TAT) for acute cases, including acute myeloid leukemia, was reported to range from 2 to 7 calendar days to 15 to 21 calendar days, with different approaches to achieving rapid TAT described. To help guide NGS panel design and standardize gene content, consensus gene lists based on current and future NGS panels in development were generated. Most survey respondents expected molecular testing at academic laboratories to continue to be viable in the future, with rapid TAT for acute cases likely to remain an important factor. Molecular testing reimbursement was reported to be a major concern. The results of this survey and subsequent discussions improve the shared understanding of differences in testing practices for hematologic malignancies between institutions and will help provide a more consistent level of patient care.
Details
- Title: Subtitle
- Current clinical practices and challenges in molecular testing: a GOAL Consortium Hematopathology Working Group report
- Creators
- Thomas D. Lee - University of California, Los AngelesDara L. Aisner - University of Colorado Anschutz Medical CampusMarjorie P. David - The University of Texas Health Science Center at San AntonioCeleste C. Eno - Cedars-Sinai Medical CenterJeffrey Gagan - The University of Texas Southwestern Medical CenterChristopher D. Gocke - Johns Hopkins MedicineNatalya V. Guseva - University of IowaLisa Haley - Johns Hopkins MedicineAudrey N. Jajosky - University of Rochester Medical CenterDaniel Jones - The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research InstituteMahesh M. Mansukhani - Columbia University Irving Medical CenterPawel Mroz - University of MinnesotaSarah S. Murray - University of California, San DiegoKimberly J. Newsom - University of FloridaVera Paulson - University of WashingtonSomak Roy - Cincinnati Children's Hospital Medical CenterChase Rushton - University of PennsylvaniaJeremy P. Segal - University of ChicagoT. Niroshini Senaratne - University of California, Los AngelesAlexa J. Siddon - Yale UniversityPetr Starostik - University of FloridaJessica A. G. Van Ziffle - University of California, San FranciscoDavid Wu - University of WashingtonRena R. Xian - Johns Hopkins MedicineSophia Yohe - University of MinnesotaAnnette S. Kim - Brigham and Women's Hospital
- Resource Type
- Journal article
- Publication Details
- Blood advances, Vol.7(16), pp.4599-4607
- Publisher
- Elsevier Inc
- DOI
- 10.1182/bloodadvances.2023010149
- PMID
- 37236162
- PMCID
- PMC10425685
- ISSN
- 2473-9529
- eISSN
- 2473-9537
- Language
- English
- Date published
- 08/22/2023
- Academic Unit
- Pathology
- Record Identifier
- 9984647059902771
Metrics
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