Current evidence supporting a goal of singletons: a review of maternal and perinatal outcomes associated with twin versus singleton pregnancies after in vitro fertilization and intracytoplasmic sperm injection

Abey Eapen; Ginny L. Ryan; Patrick Ten Eyck; Bradley J. Van Voorhis

doi:10.1016/j.fertnstert.2020.08.1423

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Current evidence supporting a goal of singletons: a review of maternal and perinatal outcomes associated with twin versus singleton pregnancies after in vitro fertilization and intracytoplasmic sperm injection

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Current evidence supporting a goal of singletons: a review of maternal and perinatal outcomes associated with twin versus singleton pregnancies after in vitro fertilization and intracytoplasmic sperm injection

Abey Eapen, Ginny L. Ryan, Patrick Ten Eyck and Bradley J. Van Voorhis

Fertility and sterility, Vol.114(4), pp.690-714

10/2020

DOI: 10.1016/j.fertnstert.2020.08.1423

PMCID: PMC8577493

PMID: 33040979

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Abstract

With increasing use of in vitro fertilization and intracytoplasmic sperm injection (IVF-ICSI) almost 2% of all babies born in the United States each year are now conceived with these technologies, making outcomes of IVF-ICSI extremely important not only to patients and families but to public health. Twin pregnancy rates after IVF-ICSI in the United States have declined since their peak in 2013 but remain at approximately 1 in 10 to 1 in 20 pregnancies. A review of the current international literature on twin versus singleton pregnancy outcomes after IVF-ICSI treatment confirms statistically significantly higher risks to maternal and perinatal health and statistically significantly higher health care costs. The field of infertility care should continue to work to develop practices that lower twin pregnancy rates to an absolute minimum to maximize the safety of these medical treatments.

Health care costs

infertility

in vitro fertilization

maternal outcomes

multiple gestation pregnancy

perinatal outcomes

twins

Details

Title: Subtitle: Current evidence supporting a goal of singletons: a review of maternal and perinatal outcomes associated with twin versus singleton pregnancies after in vitro fertilization and intracytoplasmic sperm injection
Creators: Abey Eapen - University of Iowa
Ginny L. Ryan - University of Iowa
Patrick Ten Eyck - University of Iowa
Bradley J. Van Voorhis - University of Iowa
Resource Type: Journal article
Publication Details: Fertility and sterility, Vol.114(4), pp.690-714
Publisher: Elsevier Inc
DOI: 10.1016/j.fertnstert.2020.08.1423
PMID: 33040979
PMCID: PMC8577493
ISSN: 0015-0282
eISSN: 1556-5653
Grant note: University of Iowa Institute for Clinical and Translational Science
Language: English
Date published: 10/2020
Academic Unit: Biostatistics; Obstetrics and Gynecology
Record Identifier: 9984318324402771

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