Journal article
Current issues in the management of endometrial cancer
Mayo Clinic proceedings, Vol.83(1), pp.97-112
01/01/2008
DOI: 10.4065/83.1.97
PMID: 18174012
Abstract
Endometrial cancer (EC) remains the most common gynecologic malignancy in the United States. It is expected to become more common as the prevalence of obesity, one of the most common risk factors for EC, increases worldwide. The 2 main histologic subcategories of EC, endometriold and nonendometriold EC, show unique molecular aberrations and are responsible for markedly disparate clinical behaviors. The primary treatment of EC is surgery, le, hysterectomy, removal of the adnexa, and pelvic and para-aortic lymphadenectomy, either via laparotomy or endoscopic techniques. Adjuvant therapy is necessary for patients at high risk of recurrence and consists of vaginal brachytherapy, teletherapy, systemic chemotherapy, or some combination thereof. Multi-institutional trials are in progress in this country and in Europe to better define optimal adjuvant treatment for subsets of patients, as well as the role of surgical staging in reducing both overuse and underuse of radiation therapy. Hormonal therapy is an option for some young women with EC who wish to preserve fertility. This review summarizes the diagnosis and management of EC and discusses current controversies and upcoming investigations pertaining to EC staging and adjuvant treatment.
Details
- Title: Subtitle
- Current issues in the management of endometrial cancer
- Creators
- Jamie N. Bakkum-Gamez - Mayo ClinicJesus Gonzalez-Bosquet - Mayo ClinicNadia N. Laack - Department of Radiation Oncology, Mayo Clinic, Rochester, MN;Andrea Mariani - Mayo ClinicSean C. Dowdy - Mayo Clinic
- Resource Type
- Journal article
- Publication Details
- Mayo Clinic proceedings, Vol.83(1), pp.97-112
- Publisher
- Elsevier
- DOI
- 10.4065/83.1.97
- PMID
- 18174012
- ISSN
- 0025-6196
- eISSN
- 1942-5546
- Number of pages
- 16
- Language
- English
- Date published
- 01/01/2008
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9984315562902771
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