Current status and evolving role of abuse-deterrent opioids in managing patients with chronic pain

Lynn Webster; Barbara St Marie; Bill McCarberg; Steven D Passik; Sunil J Panchal; Eric Voth

doi:10.5055/jom.2011.0066

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Current status and evolving role of abuse-deterrent opioids in managing patients with chronic pain

Journal article

Peer reviewed

Current status and evolving role of abuse-deterrent opioids in managing patients with chronic pain

Lynn Webster, Barbara St Marie, Bill McCarberg, Steven D Passik, Sunil J Panchal and Eric Voth

Journal of opioid management, Vol.7(3), pp.235-245

05/2011

DOI: 10.5055/jom.2011.0066

PMID: 21823554

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Abstract

Opioids are widely used for the treatment of patients with chronic pain; yet, the increase in their abuse, misuse, and diversion is an ongoing focus of regulatory, governmental, and legal scrutiny. As a consequence, clinicians are faced with numerous challenges in an effort to use opioids in appropriate patients with pain while minimizing the potential for opioid abuse, misuse, and diversion. Policies and programs such as state prescription monitoring programs, which have been in existence for decades, are but one attempt to address some of the issues regarding the prescribing of opioids. Another is a risk evaluation and mitigation strategy for opioids under consideration by the US Food and Drug Administration. At the clinical level, a universal precautions and risk management package that includes risk assessment and patient monitoring is a recommended approach. This approach can also include the use of abuse-deterrent and abuse-resistant formulations designed to reduce the nonmedical use of opioids. Several of these opioid formulations have been approved or should soon be on the market for use in the United States; however, their role and other questions regarding their use remain unanswered. The authors offer their clinical perspective on several of these key questions.

Analgesics, Opioid - administration & dosage

Analgesics, Opioid - chemistry

Analgesics, Opioid - therapeutic use

Chemistry, Pharmaceutical

Chronic Disease

Delayed-Action Preparations

Drug and Narcotic Control

Drug Industry

Drug Monitoring

Government Regulation

Humans

Opioid-Related Disorders - prevention & control

Pain - drug therapy

Pharmacology, Clinical

Risk Management

United States

Details

Title: Subtitle: Current status and evolving role of abuse-deterrent opioids in managing patients with chronic pain
Creators: Lynn Webster - Lifetree Clinical Research and Pain Clinic, Salt Lake City, Utah, USA.
Barbara St Marie
Bill McCarberg
Steven D Passik
Sunil J Panchal
Eric Voth
Resource Type: Journal article
Publication Details: Journal of opioid management, Vol.7(3), pp.235-245
DOI: 10.5055/jom.2011.0066
PMID: 21823554
NLM abbreviation: J Opioid Manag
ISSN: 1551-7489
eISSN: 2375-0146
Language: English
Date published: 05/2011
Academic Unit: Addiction Medicine; Nursing; Injury Prevention Research Center
Record Identifier: 9984370738702771

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